BACKGROUND In Drosophila melanogaster the Enhancer of split-Complex [E(spl)-C] consists of seven highly related genes encoding basic helix-loop-helix (bHLH) repressors and intermingled, four genes that belong to the Bearded (Brd) family. Both gene classes are targets of the Notch signalling pathway. The Achaete-Scute-Complex [AS-C] comprises four genes… (More)
Apoptosis is regulated by several signaling pathways which are extensively linked by crosstalks. Boolean or logical modeling has become a promising approach to capture the qualitative behavior of such complex networks. Here we built a large-scale literature-based Boolean model of the central intrinsic and extrinsic apoptosis pathways as well as pathways… (More)
BACKGROUND The decision pro- or contra apoptosis is complex, involves a number of different inputs, and is central for the homeostasis of an individual cell as well as for the maintenance and regeneration of the complete organism. RESULTS This study centers on Fas ligand (FasL)-mediated apoptosis, and a complex and internally strongly linked network is… (More)
The proinflammatory cytokine TNFα fails to provoke cell death in isolated hepatocytes but has been implicated in hepatocyte apoptosis during liver diseases associated with chronic inflammation. Recently, we showed that TNFα is able to sensitize primary murine hepatocytes cultured on collagen to Fas ligand-induced apoptosis and presented a mathematical model… (More)
The number of mathematical models for biological pathways is rapidly growing. In particular, Boolean modelling proved to be suited to describe large cellular signalling networks. Systems biology is at the threshold to holistic understanding of comprehensive networks. In order to reach this goal, connection and integration of existing models of parts of… (More)
Logical modeling is an appropriate approach to cover large-scale biological signal transduction networks. However, the large size of the resulting models lead to problems especially regarding appropriate experimental model validation.
Mathematical modeling and model analysis of biochemical reaction networks are becoming important tools for biological research and for applications in medicine and bioprocess engineering. We will discuss the special role of mathematical modeling in biological research. In engineering applications, models are primarily means to accomplish a design task (e.g.… (More)