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A high-coverage Neandertal genome from Vindija Cave in Croatia
TLDR
The genome of a female Neandertal from ~50,000 years ago from Vindija Cave, Croatia, is sequenced to ~30-fold genomic coverage, allowing 10 to 20% more Ne andertal DNA to be identified in present-day humans, including variants involved in low-density lipoprotein cholesterol concentrations, schizophrenia, and other diseases.
Excess of genomic defects in a woolly mammoth on Wrangel island
TLDR
This work identifies deletions, retrogenes, and non-functionalizing point mutations in woolly mammoths from an isolated population on Wrangel island where mammoths subsisted with small effective population size more than 43-fold lower than previous populations.
Landscape of Standing Variation for Tandem Duplications in Drosophila yakuba and Drosophila simulans
TLDR
The results suggest that tandem duplications often result in complex variation beyond whole gene duplications that offers a rich substrate of standing variation that is likely to contribute both to detrimental phenotypes and disease, as well as to adaptive evolutionary change.
Formation and Longevity of Chimeric and Duplicate Genes in Drosophila melanogaster
TLDR
A dynamic picture is painted of both chimeras and duplicate genes within the genome and it is suggested that chimeric genes contribute substantially to genomic novelty.
Chimeric genes as a source of rapid evolution in Drosophila melanogaster.
TLDR
It is demonstrated that chimeric gene formation can produce qualitative expression changes that are difficult to mimic through duplicate gene formation, and that extremely young chimeric genes (d(S) < 0.03) are more likely to be associated with selective sweeps than duplicate genes of the same age.
Genomic Takeover by Transposable Elements in the Strawberry Poison Frog
TLDR
The complement of ion channels in the first genomic sequenced poison frog is identified and its relation to the evolution of autoresistance to toxins sequestered in the skin is discussed.
Adaptive impact of the chimeric gene Quetzalcoatl in Drosophila melanogaster
TLDR
Results show that chimeric genes can produce structural and regulatory changes in a single mutational step and may be a major factor in adaptive evolution.
Chromosomal Rearrangements as Barriers to Genetic Homogenization between Archaic and Modern Humans.
Chromosomal rearrangements, which shuffle DNA throughout the genome, are an important source of divergence across taxa. Using a paired-end read approach with Illumina sequence data for archaic
Revised Annotations, Sex-Biased Expression, and Lineage-Specific Genes in the Drosophila melanogaster Group
Here, we provide revised gene models for D. ananassae, D. yakuba, and D. simulans, which include untranslated regions and empirically verified intron-exon boundaries, as well as ortholog groups
Tandem duplications lead to novel expression patterns through exon shuffling in Drosophila yakuba
TLDR
The value of tandem duplications is likely to be more intricate than simple changes in gene dosage, as changes in expression level due to both shuffling of regulatory elements and the creation of chimeric structures via tandem duplication are observed.
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