Rebekah Bosse

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The impact of gonadal hormone withdrawal and estrogen therapy was investigated on the rat dopamine transporter (DAT). Short-term ovariectomized (ST-OVX, 2 weeks) and long-term ovariectomized (LT-OVX, 3 months) rats were treated or not with 17beta-estradiol (E2) for 2 weeks. DAT mRNA expression was measured by in situ hybridization in the substantia nigra(More)
The effect of short-term (Sprague-Dawley rats, two weeks) and long-term ovariectomy (Sprague-Dawley and Fischer rats, three months) on serotonin 5-hydroxytryptamine2A receptors in different regions of the brain and its possible correction with an 17 beta-estradiol treatment (10 micrograms, b.i.d., two weeks) were studied in comparison to intact rats.(More)
[Sar1,Phe(Br5)8] angiotensin II (Br5Ang II) is a specific, quasi-irreversible antagonist of angiotensin II (Ang II) in vitro. In vivo, this compound is a very potent, Ang II-specific antagonist with a very long duration of action against Ang II-induced blood pressure (BP) increases. In the "low-sodium" dog, this compound induces a prolonged BP reduction(More)
A peak of first episodes of schizophrenia can occur in postmenopausal women. Furthermore, tardive dyskinesia is more common in postmenopausal women than in men of comparable age. This study investigated the effect of ovariectomy (2 weeks or 3 months) in rats as a model of decreased gonadal function associated with menopause. After ovariectomy, frontal(More)
Previous photoaffinity labeling of angiotensin II (Ang) receptors with azidophenylalanine containing Ang analogs produced high yield labeling of a 60 kDa protein on bovine adrenocortical membranes. This preparation is mostly enriched in the type 1 Ang receptor (AT1) and AT1 selective ligands (L158,809) totally prevented labeling, therefore confirming the(More)
Angiotensin II (AII) binding sites were characterized in human myometrium membrane preparations. The sites were saturable and of high affinity (Kd of 0.09 nM and Bmax of about 200 fmol/mg of protein). PD 123319 completely inhibited 125I-AII binding, with an IC50 of 30 nM, whereas L-158,809 (1 microM) had no significant effect on 125I-AII binding. These(More)
We provide details on 46 microsatellite loci for Crotalus and Sistrurus rattlesnake species. We isolated 14, five, and four novel polymorphic species-specific microsatellite markers for Crotalus atrox, C. scutulatus, and C. cerastes, respectively. We observed seven to 36 alleles per locus. Additionally, we provide data on the cross-species amplification of(More)
We have synthesized a potent, selective, radioiodinated bradykinin (BK) analogue with high specific radioactivity (1000-1500 Ci/mmol). The new tracer, 125I-[p-Phe5]BK, was prepared carrier-free from the corresponding nitro precursor, [p-NO2-Phe5]BK, via catalytic hydrogenation and halodediazotation. This peptide bound to guinea pig ileum membranes in a(More)