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The Hippo signalling pathway regulates cellular proliferation and survival, thus has profound effects on normal cell fate and tumorigenesis. The pivotal effector of this pathway is YAP (yes-associated protein), a transcriptional co-activator amplified in mouse and human cancers, where it promotes epithelial to mesenchymal transition (EMT) and malignant(More)
BACKGROUND Intravenous (IV) amiodarone has proven efficacy in adults. However, its use in children is based on limited retrospective data. METHODS AND RESULTS A double-blind, randomized, multicenter, dose-response study of the safety and efficacy of IV amiodarone was conducted in 61 children (30 days to 14.9 years; median, 1.6 years). Children with(More)
Many studies have used host-parasite systems to study local adaptation, but few of these studies have found unequivocal evidence for adaptation. One potential reason is that most studies have focused on limited measures of host and parasite fitness that are generally assumed to be under negative frequency-dependent selection. We have used reciprocal(More)
BACKGROUND While most children with cancer survive their initial disease, cancer therapy places them at risk for late effects (LE). Knowledge of their diagnosis, treatment, and LE risk may motivate survivors to attend long-term follow-up care. The aims of this study were to examine knowledge of cancer history and future risks, and to identify factors(More)
PURPOSE Adolescent and young adult (AYA) survivors of cancers in childhood experience cancer worry, defined as concerns about cancer-related issues such as relapse and late effects of treatment. Cancer worry is an important determinant of successful transition to long-term follow-up care. The primary aim of this study was to identify patient-, cancer-, and(More)
Patient safety is a key concern for pharmaceutical companies. The external environment and regulatory requirements have changed considerably over recent years. Risk management planning is becoming increasingly important, partly because of a number of high profile safety issues that have led to the withdrawal of marketed products. Openness, accountability(More)
The Noordhoff Craniofacial Foundation and Chang Gung Memorial Hospital have partnered to deliver cleft programs to developing nations still in need of adequate cleft care. The lessons learnt through the development of the Chang Gung Cleft and Craniofacial Center from humble beginnings to its current international standing have enabled insights into devising(More)
The purpose of this experiment is to test if there is a potential for human toxicity to sodium arsenite (NaAsO2) by examining cell death in A549 cells acutely exposed NaAsO2. In this experiment, A549 cells were plated according to experimental requirements and grown to 70 80% confluence before treatment with NaAsO2 of different concentrations. Methylthiazol(More)
In a prospective, randomized, parallel study, two regimens of platelet-suppressant therapy (PST) dipyridamole-aspirin and pentoxifylline-aspirin were compared with standard oral anticoagulation with warfarin in the prevention of prosthetic heart valve thromboembolism. In the entire group of 254 patients followed for 395.6 patient-years, the thromboembolic(More)