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A microfluidic platform for chemical stimulation and real time analysis of catecholamine secretion from neuroendocrine cells.
TLDR
Overall, this microfluidic device can be used to implement complex stimulation paradigms and analyze the amount and kinetics of catecholamine secretion from small populations of neuroendocrine cells in real time. Expand
Serotonin and Serotonin Transporters in the Adrenal Medulla: A Potential Hub for Modulation of the Sympathetic Stress Response.
TLDR
A model is proposed in which stress-evoked adrenal catecholamine secretion is fine-tuned by SERT-modulated autocrine 5-HT signaling, which raises the possibility that the adrenal medulla is a previously unrecognized peripheral hub for serotonergic control of the sympathetic stress response. Expand
An interplay between the serotonin transporter (SERT) and 5-HT receptors controls stimulus-secretion coupling in sympathoadrenal chromaffin cells
TLDR
Carbon fibre amperometry showed that SERT modulated the ability of 5-HT1A receptors to inhibit exocytosis, revealing a novel role for SERT and suggesting that adrenal chromaffin cells might be a previously unrecognized hub for serotonergic control of the sympathetic stress response. Expand
Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes
TLDR
In in vitro fusion assays using full-length t- and v-SNAREs embedded in liposomes, Gβγ inhibited Ca2+/synaptotagmin-dependent fusion and showed that the target of G βγ, downstream of VGCC, is the membrane-embedded SNARE complex. Expand
Gabapentin Inhibits Catecholamine Release from Adrenal Chromaffin Cells
TLDR
The work demonstrates that chromaffin cells are a useful model for additional investigation of the cellular mechanism(s) by which gabapentin controls neurosecretion and identifies altered adrenal catecholamine release as a potential contributor to some of the beneficial perioperative effects of gABapentin. Expand
Sigma‐1 receptor ligands inhibit catecholamine secretion from adrenal chromaffin cells due to block of nicotinic acetylcholine receptors
TLDR
SSRIs and other sigma‐1 receptor ligands inhibit secretion evoked by cholinergic stimulation because of direct block of Ca2+entry via nAChRs, suggesting that s Sigma‐1 receptors do not acutely regulate catecholamine secretion. Expand
Adrenal serotonin derives from accumulation by the antidepressant‐sensitive serotonin transporter
TLDR
This novel model confirms that SERT expressed in adrenal chromaffin cells is essential for maintaining wild‐type levels of 5‐HT and provides a powerful tool to help dissect the role of SERT in the sympathetic stress response. Expand
Butanol Isomers Exert Distinct Effects on Voltage-Gated Calcium Channel Currents and Thus Catecholamine Secretion in Adrenal Chromaffin Cells
TLDR
It is shown that 1- butanol reduces catecholamine secretion from adrenal chromaffin cells to a much greater extent than tert-butanol, and that the PLD inhibitor VU0155056 has no effect. Expand
Jedi-1 deficiency increases sensory neuron excitability through a non-cell autonomous mechanism
TLDR
It is indicated that loss of Jedi-1 alters DRG neuron activity indirectly through an intercellular interaction between non-neuronal cells and sensory neurons, as well as alterations in the properties of voltage-gated sodium channel currents in Jedi- 1 null neurons. Expand
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