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Parkinson's disease (PD) is a common neurodegenerative disorder with a lifetime incidence of approximately 2 percent. A pattern of familial aggregation has been documented for the disorder, and it was recently reported that a PD susceptibility gene in a large Italian kindred is located on the long arm of human chromosome 4. A mutation was identified in the(More)
Parkinson's disease (PD) is a common neurodegen-erative movement disorder characterized by tremor, bradykinesia, postural instability and muscular rigidity. Neuropathologically, it is defined by cell loss in the sub-stantia nigra associated with the presence of intraneu-ronal inclusions called Lewy bodies (LB) and processes engorged with proteinaceous(More)
Peutz-Jeghers syndrome (PJS) is an autosomal dominant condition characterized by intestinal hamartomatous polyps, mucocutaneous melanin deposition, and increased risk of cancer. Families with PJS from the Johns Hopkins Polyposis Registry were studied to identify the molecular basis of this syndrome and to characterize the pathogenesis of gastrointestinal(More)
We have constructed a yeast artificial chromosome contig (YAC) map of human chromosome 4q21-q23 across the Parkinson's disease region by combining molecular and fluorescence in situ hybridization techniques. This map contains 55 YACs and 51 molecular markers, including 23 polymorphic markers. We have also isolated one P1 and 33 bacterial artificial(More)
INTRODUCTION AND HYPOTHESIS Despite the lack of evidence, antibiotic prophylaxis has been recommended for midurethral sling procedures. The goal of this study was to evaluate the rate of infectious complications in women undergoing midurethral sling procedures without antibiotic prophylaxis. METHODS We reviewed the baseline characteristics and(More)
This report has been reviewed by the staff of the Air Resources Board and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the Air Resources Board. Mention of trade names or commercial products does not constitute endorsement or recommendation for their use. iii Acknowledgements In addition,(More)