Rebecca L Baldwin

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Persons affected with tuberous sclerosis complex (TSC) develop a wide range of neurological abnormalities including aberrant neuronal migration and seizures. In an effort to model TSC-associated central nervous system abnormalities in mice, we generated two independent lines of astrocyte-specific Tsc1 conditional knockout mice by using the Cre-LoxP system.(More)
A significant proportion of human malignant gliomas exhibit amplification, overexpression, or mutations of the epidermal growth factor receptor (EGFR). To define the functional role(s) of the EGFR in the pathogenesis of gliomas, we established transgenic mice that express both wild-type (wt) and mutant (EGFRvIII) EGFR molecules using the human glial(More)
We first present a brief discussion of early and current models (feeding systems) used to estimate animal energy and protein requirements and to predict performance based on feed composition and intake. We then touch on some limitations inherent in these systems. Next, we propose that dynamic (i.e. time-variant) models and mechanistic models (i.e. equations(More)
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