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Extracelluar signal-regulated kinase (ERK) pathway activation has been demonstrated following convulsant stimulation; however, little is known about the molecular targets of ERK in seizure models. Recently, it has been shown that ERK phosphorylates Kv4.2 channels leading to down-regulation of channel function, and substantially alters dendritic(More)
Transcription factors interferon regulatory factor 3 (IRF3) and nuclear factor κB (NFκB) are activated by external stimuli, including virus infection, to translocate to the nucleus and bind genomic targets important for immunity and inflammation. To investigate RNA polymerase II (Pol II) recruitment and elongation in the human antiviral gene regulatory(More)
Genome-wide investigations have dramatically increased our understanding of nucleosome positioning and the role of chromatin in gene regulation, yet some genomic regions have been poorly represented in human nucleosome maps. One such region is represented by human chromosome 9p21-22, which contains the type I interferon gene cluster that includes 16(More)
T he modern OR is a marvel of complex, multidisciplinary teamwork. A team of surgeons, anesthesiologists, certified RN anesthetists, nurses, and surgical technologists, backed by numerous support staff members, must work together as a cohesive and coordinated unit to safely care for a patient before, during, and after a surgical procedure. When an OR is(More)
The religion literature in Sociology remains largely disconnected from the ethnicity and immigration literature despite enduring connections between religion and ethnicity. This review helps to close this gap. It shows how the dominant theories in each discipline follow a similar trajectory and examines how exploring the theoretical connections between(More)
In this study, we take advantage of the high spatial resolution offered by the nucleus and lampbrush chromosomes of the amphibian oocyte to investigate the mechanisms that regulate the intranuclear trafficking of the U5 snRNP and its recruitment to nascent transcripts. We monitor the fate of newly assembled fluorescent U5 snRNP in Xenopus oocytes depleted(More)
Patients who have had surgical bladder augmentation have an increased risk of bladder malignancy, though the mechanism for this increased risk is unknown. Hyperosmolal microenvironments such as the bladder may impair DNA damage signaling and repair; this effect may be more pronounced in tissues not normally exposed to such conditions. Comparing gastric and(More)
We report two cases of idiopathic choroidal neovascularization (CNV) in pediatric patients treated with intravitreal ranibizumab injections (IVRs). A nine-year-old girl with decreased visual acuity in the left eye (20/100) was diagnosed with idiopathic CNV (case 1). The fluorescein angiography (FAG), indocyanine green angiography (ICG), and optical(More)
BACKGROUND Evaluation of quality of life (QOL) measures is increasingly being valued as an essential parameter to determine treatment results after head and neck reconstruction. The present study was designed to evaluate the effect of microsurgical reconstruction on patient-reported QOL. METHODS Patients undergoing microsurgical reconstruction after(More)
IMPORTANCE Little is known about the sustainability and long-term effect of surgical safety checklists when implemented in resource-limited settings. A previous study demonstrated the marked, short-term effect of a structured hospital-wide implementation of a surgical safety checklist in Moldova, a lower-middle-income country, as have studies in other(More)