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  • Holly G. Davies, Rebecca J. Richter, Matthew Keifer, Clarence A. Broomfield, Jason Sowalla, Clement E. Furlong
  • Medicine, Biology
  • Nature Genetics
  • 1996 (First Publication: 1 November 1996)
  • Many organophosphorus compounds (OPs) are potent cholinesterase inhibitors, accounting for their use as insecticides and, unfortunately, also as nerve agents. Each year there are approximately 3Expand
  • Gail P. Jarvik, Laura S. Rozek, +4 authors Clement E. Furlong
  • Biology, Medicine
  • Arteriosclerosis, thrombosis, and vascular…
  • 2000 (First Publication: 1 November 2000)
  • The paraoxonase (PON1) PON1-Q192R and PON1-L55M polymorphisms have been inconsistently associated with vascular disease. Plasma PON1 activity phenotypes vary markedly within genotypes and were,Expand
  • Lucio Guido Costa, Wei Fen Li, Rebecca J. Richter, Diana M. Shih, Aldons J. Lusis, Clement E. Furlong
  • Medicine, Biology
  • Chemico-biological interactions
  • 1999 (First Publication: 1 May 1999)
  • In human populations, serum paraoxonase (PON1) exhibits a substrate dependent polymorphism. The Arg192 isoform hydrolyzes paraoxon rapidly but diazoxon, soman and especially sarin slowly. On theExpand
  • Clement E. Furlong, Rebecca J. Richter, S L Seidel, Lucio Guido Costa, Arno G. Motulsky
  • Chemistry, Medicine
  • Analytical biochemistry
  • 1989 (First Publication: 1 August 1989)
  • Human serum plasma paraoxonase/arylesterase exhibits a genetic polymorphism for the hydrolysis of paraoxon. One allelic form of the enzyme hydrolyzes paraoxon slowly with a low turnover number andExpand
  • Lucio Guido Costa, Rebecca J. Richter, Wan-Fen Li, Toby B. Cole, Marina Guizzetti, Clement E. Furlong
  • Medicine, Biology
  • Biomarkers : biochemical indicators of exposure…
  • 2003 (First Publication: 1 January 2003)
  • Paraoxonase (PON1) is an A-esterase capable of hydrolysing the active metabolites (oxons) of a number of organophosphorus (OP) insecticides such as parathion, diazinon and chlorpyrifos. PON1 activityExpand
  • Toby B. Cole, Betsy J Walter, +6 authors Clement E. Furlong
  • Medicine, Biology
  • Pharmacogenetics and genomics
  • 2005 (First Publication: 1 August 2005)
  • Objectives The Q192R polymorphism of paraoxonase (PON1) has been shown to affect hydrolysis of organophosphorus compounds. The Q192 and R192 alloforms exhibit equivalent catalytic efficiencies ofExpand