Rebecca J. Jackman

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This paper describes a procedure for making topologically complex three-dimensional microfluidic channel systems in poly(dimethylsiloxane) (PDMS). This procedure is called the "membrane sandwich" method to suggest the structure of the final system: a thin membrane having channel structures molded on each face (and with connections between the faces)(More)
This paper describes the fabrication of large (up to 45 cm(2)) arrays of microwells, with volumes as small as ∼3 fL/well and densities as high as 10(7) wells/cm(2). These arrays of microwells are formed by casting an elastomer, poly(dimethylsiloxane) (PDMS), against "masters" prepared by photolithography; arrays of microwells in other polymers can be formed(More)
Elastomeric membranes that contained regular arrays of well-defined holes were formed by spin-coating a prepolymer onto a photolithographically defined master. These membranes were used as dry resists or as masks in dry lift-off to produce simple features as small as 5 μm on both planar and nonplanar surfaces. These procedures were “dry” because the(More)
The phase separation of ultrathin polymer-blend films of polystyrene and polybutadiene on microcontact printed alkanethiol patterns with hydrophobic and hydrophilic end groups (2CH3 and 2COOH! is investigated by atomic force microscopy. Simulations suggest that the phase-separation morphology can be controlled through patterns that modulate the(More)
Several non-photolithographic methods for growing patterned films of parylene-based polymers prepared by chemical vapor deposition are presented. These patterns were generated using transition metals and metal salts known to inhibit polymer deposition, in combination with alkanethiols deposited by microcontact printing. By patterning the alkanethiols on(More)
Microcontact printing (mu CP) has been used to produce patterned self-assembled monolayers (SAMs) with submicrometer features on curved substrates with radii of curvature as small as 25 micrometers. Wet-chemical etching that uses the patterned SAMs as resists transfers the patterns formed by mu CP into gold. At present, there is no comparable method for(More)
BACKGROUND Two complementary approaches to studying the cellular function of proteins involve alteration of function either by mutating protein-encoding genes or by binding a small molecule to the protein. A mutagen can generate millions of genetic mutations; correspondingly, split-pool synthesis can generate millions of unique ligands attached to(More)
This paper describes optical components prepared using poly(dimethylsiloxane) elastomers and liquid metals as constituent materials. Most optical components are fabricated from rigid materials such as glass, rigid polymers, or metals. By contrast, the elastomeric optics described here are designed to be deformable. Because the structure of the optical(More)
Soft lithography offers a convenient set of methods for the transfer of patterns to planar and nonplanar substrates. Microelectrodeposition can transform thin metal patterns into self-supporting microstructures, weld components together, and strengthen microstructures after deformations. Together, soft lithography and electrochemistry provide synergistic(More)
We describe the analysis of heat flow in a type of tunable optical fiber grating that uses thin-film resistive heaters microfabricated on the surface of the fiber. The high rate of heat loss from these microstructures and the relatively low thermal diffusivity of the glass yield unusual thermal properties. Approximate one-dimensional analytical calculations(More)