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Discovery of a fusion kinase in EOL-1 cells and idiopathic hypereosinophilic syndrome
TLDR
A genetic rearrangement in the eosinophilic cell line EOL-1 is identified that results in the expression of a fusion protein comprising an N-terminal region encoded by a gene of unknown function with the GenBank accession number NM_030917 and a C-Terminal region derived from the intracellular domain of the platelet-derived growth factor receptor α (PDGFRα).