Rebecca Gillespie

Learn More
A potent inhibitor of mitogen-stimulated T cell proliferation exists in the saliva of several species of hard ticks, including the Lyme disease vector tick, Ixodes scapularis. Our characterization of this phenomenon has led to the identification of a possible mechanism for the T cell inhibitory activity of I. scapularis saliva. The T cell inhibitor can(More)
There are potent immunomodulators in saliva of the bloodfeeding arthropods which transmit many of the world's most serious diseases that may benefit the arthropod by preventing the vertebrate host from becoming sensitized to the saliva. In addition, saliva can enhance transmission of parasites/pathogens by arthropods. As a result, vaccines that target the(More)
The density, standing stock, reproductive periodicity and alginate yields have been investigated for a mixed Sargassum species population at Reunion Rocks, KwaZulu-Natal, South Africa. The population consists of two dominant components, Sargassum elegans Suhr and a second species, here termed Sargassum sp. 1. Sargassum elegans typically makes up more than(More)
trans-Splicing is essential for mRNA maturation in trypanosomatids. A conserved AG dinucleotide serves as the 3' splice acceptor site, and analysis of native processing sites suggests that selection of this site is determined according to a 5'-3' scanning model. A series of stable gene replacement lines were generated that carried point mutations at or near(More)
Leishmania major is a protozoan parasite that is transmitted to the mammalian host by its sand fly vector when the fly probes in the host's skin for a blood meal and injects the parasite within its saliva. In mice experimentally infected with L. major, outgrowth of CD4 type 1 (Th1) cells leads to resolution of the infection, but outgrowth of type 2 (Th2)(More)
Many genes in trypanosomes exist as members of multicopy gene families. Due to this fact it is frequently difficult to determine if specific members of a gene family are expressed. We describe here a strategy for simultaneous tandem gene replacement in T. cruzi which leads to the replacement of the gene of interest by a silent reporter gene, the expression(More)
For socially appropriate communication, speakers must command a variety of linguistic styles, or registers, that vary according to social context and social relationships. This study examined preschool children's ability to use a speaker's register choice to infer the identity of their addressee. Four-year-olds could draw correct inferences based on Spanish(More)