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TET2 is a close relative of TET1, an enzyme that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. The gene encoding TET2 resides at chromosome 4q24, in a region showing recurrent microdeletions and copy-neutral loss of heterozygosity (CN-LOH) in patients with diverse myeloid malignancies. Somatic TET2 mutations are frequently(More)
Because the concept of program correctness is generally taught as an activity independent of the programming process, most introductory computer science (CS) students perceive it as unnecessary and even irrelevant. The concept of contracts, on the other hand, is generally taught as an integral part of the programming process. As such, most introductory CS(More)
In an attempt to better integrate discrete mathematics into the introductory CS curriculum, we implemented ProVIDE, an enhanced integrated development environment (IDE) for Java that enables students to analyze their computer programs (in terms of their correctness) while they are creating them [1]. The primary goal of the construction of ProVIDE is the(More)
Limb body wall complex (LBWC) and amniotic band sequence (ABS) are multiple congenital anomaly conditions with craniofacial, limb, and ventral wall defects. LBWC and ABS are considered separate entities by some, and a continuum of severity of the same condition by others. The etiology of LBWC/ABS remains unknown and multiple hypotheses have been proposed.(More)
The epidermal growth factor receptor (EGFR) is part of a large family of receptors required for communicating extracellular signals through internal tyrosine kinases. Epidermal growth factor (EGF) signaling is required for tissue development, whereas constitutive activation of this signaling pathway is associated with oncogenic transformation. We identified(More)
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