Rebecca Brockman

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The 2-fluoro derivative of 9-beta-D-arabinofuranosyladenine (2-F-ara-A) and its soluble 5'-formate and 5'-phosphate derivatives were therapeutically effective against the parent leukemia L1210 (L1210/0). 2-F-ara-A and 9-beta-D-arabinofuranosyladenine 5'-formate were inactive aginst a 1-beta-D-arabinofuranosylcytosine-resistant subline (L1210/ara-C) that was(More)
Gonadal steroids modify the phase, amplitude and period of circadian rhythms. To further resolve the role of estradiol, we examined daily patterns of activity, circadian free running period and behavioral responses to light pulses using aromatase deficient (ArKO) mice. These animals lack the enzyme necessary to produce estradiol. We hypothesized that(More)
A nucleoside kinase has been purified about 1680-fold from L1210 leukemia cells with deoxyadenosine as the phosphate acceptor and with adenosine triphosphate as phosphate donor. The molecular weight of the enzyme, determined by Sephadex G-200 column chromatography, was found to be about 100,-000. Purified enzyme, after the final step of purification and(More)
Cimetidine, the first of a new class of pharmacologic agents that dramatically inhibit basal gastric acid secretion, is achieving widespread use for the treatment of such acid peptic disorders as duodenal ulcers, gastritis, and reflux esophagitis. Three patients are presented who experienced agitation, disorientation, and hallucinations while being treated(More)
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