Rebecca Begley

Learn More
We used DNA microarrays to profile gene expression patterns in the C. elegans germline and identified 1416 germline-enriched transcripts that define three groups. The sperm-enriched group contains an unusually large number of protein kinases and phosphatases. The oocyte-enriched group includes potentially new components of embryonic signaling pathways. The(More)
In C. elegans, let-60 Ras controls many cellular processes such as differentiation of vulval epithelial cells, function of chemosensory neurons, and meiotic progression in the germ line. Although much is known about the let-60 Ras signaling pathway, relatively little is understood about the target genes induced by let-60 Ras signaling that carry out(More)
Background—We previously showed that a selective activator peptide of ⑀-protein kinase C (PKC), ␺⑀RACK, conferred cardioprotection against ischemia-reperfusion when delivered ex vivo before the ischemic event. Here, we tested whether in vivo continuous systemic delivery of ␺⑀RACK confers sustained cardioprotection against ischemia-reperfusion in isolated(More)
MobilomeFINDER (http://mml.sjtu.edu.cn/Mobilome FINDER) is an interactive online tool that facilitates bacterial genomic island or 'mobile genome' (mobi-lome) discovery; it integrates the ArrayOme and tRNAcc software packages. ArrayOme utilizes a microarray-derived comparative genomic hybridiza-tion input data set to generate 'inferred contigs' produced by(More)
  • 1