Rebecca Baldwin

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HS (heparan sulfate) is essential for normal embryonic development. This requirement is due to the obligatory role for HS in the signalling pathways of many growth factors and morphogens that bind to sulfated domains in the HS polymer chain. The sulfation patterning of HS is determined by a complex interplay of Golgi-located N- and O-sulfotransferases which(More)
Heparan sulfate (HS) is a cell surface carbohydrate polymer modified with sulfate moieties whose highly ordered composition is central to directing specific cell signaling events. The ability of the cell to generate these information rich glycans with such specificity has opened up a new field of "heparanomics" which seeks to understand the systems involved(More)
Falls are a major cause of injuries in adults above the age of sixty-five. The economic aftermath of falls and their consequent hospitalization can be huge, totaling more than 30 billion dollars in 2010 alone. A plausible way of mitigating this problem is accurate prediction of future falls and taking proactive remedial action. Spatio-temporal variation in(More)
Red-eared slider turtles are genetically bipotential for sex determination. In this species, as in many other reptiles, incubation temperature of the egg determines gonadal sex. At higher incubation temperatures females are produced and increasing temperature appears to increase estrogen production in the embryonic brain. Treatment of eggs incubating at a(More)
Three families in which there are five patients with cerebromacular degeneration have been studied, and preliminary findings show that both the patients and some of the members of their immediate families have generalized imidazole aminoaciduria. The patients excrete large amounts of carnosine and anserine as well as histidine and 1-methyl histidine. The(More)
Heparan sulfate (HS) is a mandatory coreceptor for many growth factors and morphogens involved in embryonic development; its bioactivity is dictated by complex sulfation motifs embedded within the polymer chain. Using a panel of HS-specific antibodies we have identified a unique HS epitope recognized by antibody HS4C3 that is selectively expressed during(More)
This paper reports the cloning and characterisation of a new posterior epidermal marker, X-epilectin, in Xenopus laevis. This gene encodes for a fucolectin, which belongs to the lectin superfamily of carbohydrate binding proteins and specifically binds fucose residues. RT-PCR and in situ hybridisation show that the expression of this gene is switched on(More)