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We have engineered an industrial strain of the yeast, Candida tropicalis, for the efficient production of long-chain dicarboxylic acids, which are important raw materials for the chemical industry. By sequential disruption of the four genes encoding both isozymes of the acyl-CoA oxidase which catalyzes the first reaction in the beta-oxidation pathway,(More)
This paper describes an overall view of an industrial protein engineering project from conception to successful completion. The choice of rational design was determined by the availability of an excellent three-dimensional crystal structure and the availability of information in the literature to define a strategy. The design strategy was refined(More)
OBJECTIVES A game application, "Making Smart Choices", was developed to fill the gap of limited easy-to-access resources available on sex education in Hong Kong and to disseminate correct knowledge and positive attitudes toward sex to teenagers using popular platforms such as tablets, Facebook, and the Web. SUBJECTS AND METHODS Three versions of the game(More)
The purpose of this study is to understand collaborative sensemaking processes among middle school students in a discovery based hybrid e-learning environment. Our exploratory study reports interview findings on student experiences, and contributes to our ongoing investigation of this complex social learning system. This paper is also an effort to extend(More)
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