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PURPOSE To investigate baseline factors and neurologic function tests (NFTs) that may predict the development of grade 2 or higher peripheral neuropathy (PN) after treatment with ixabepilone, an epothilone microtubule-stabilizing agent with antitumor activity. PATIENTS AND METHODS Advanced breast cancer patients were treated with ixabepilone (6 mg/m2) for(More)
OBJECTIVE The Brief Assessment of Motor Function consists of five 0- to 10-point hierarchical scales designed for rapid assessment of gross, fine, and oral motor skills. We describe the development and evaluation of the two Brief Assessment of Motor Function Oral Motor Scales: Oral Motor Articulation and Oral Motor Deglutition. DESIGN This validation(More)
BACKGROUND In a cross-sectional study examining late effects of pediatric sarcoma therapy, long-term survivors were evaluated on their activities of daily living (ADL) performance. PROCEDURE Thirty-two persons with Ewing sarcoma family of tumors, rhabdomyosarcoma, and non-rhabdomysarcoma-soft tissue sarcoma enrolled an average of 17 years after treatment.(More)
Acknowledgments Many people generously contributed to the development of this study. We would like to thank all the researchers—faculty, staff, and students—who participated in and informed the study. We are especially grateful to Joan Herman for her insightful comments and advice. Frances Butler and Alison Bailey advised on the choice of the study's(More)
OBJECTIVE To determine the effect of HIV infection on the motor performance of children and preadolescents, the Bruininks-Oseretsky Test of Motor Proficiency (BOTMP) was administered to see whether performance scores (raw and standard) would change with duration of the disease. METHOD Thirty-four children and preadolescents were tested on the BOTMP at(More)
We used standardized neuropsychological measures of intellectual, cognitive, psychomotor, and emotional functioning to compare 39 patients with olivopontocerebellar atrophy and 25 normal controls of similar age. The patients reflected greater depression, anxiety, and subjective emotional discomfort than did the control subjects. While 4 of the patients had(More)
PURPOSE The Brief Assessment of Motor Function Fine Motor Scale (FMS) allows rapid assessment, independent of age. This study was done to establish content validity of the FMS and to demonstrate FMS reliability. METHODS A standard questionnaire ("Disagree" to "Agree," 1-4) was emailed to 28 expert panel members. Ten children with diagnoses including(More)
OBJECTIVES To describe the inter-relationships among impairments, performance, and disabilities in survivors of pediatric sarcoma and to identify measurements that profile survivors at risk for functional loss. DESIGN Prospective, cross-sectional. SETTING Research facility. PARTICIPANTS Thirty-two participants in National Cancer Institute clinical(More)
PURPOSE To assess health and musculoskeletal function in survivors of pediatric sarcomas. PATIENTS AND METHODS Thirty-two individuals treated for Ewing sarcoma family of tumors (ESFT), rhabdomyosarcoma (RMS), or non-rhabdomyosarcoma soft tissue sarcomas (NR-STS) with multi-modality therapy were enrolled on this cross-sectional study. Median age at the(More)
OBJECTIVE To determine if elderly bereaved depressed subjects display difficulty with activities of daily living (ADL) and if their ADL difficulty improves with psychopharmacologic intervention. METHOD The Assessment of Motor and Process Skills (AMPS), an ADL assessment measuring ADL motor and ADL process skills, was administered to a pilot sample of(More)