Rebecca A. Flaherty

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Streptococcus pyogenes, or group A Streptococcus (GAS), is a pathogen that causes a multitude of human diseases from pharyngitis to severe infections such as toxic shock syndrome and necrotizing fasciitis. One of the primary virulence factors produced by GAS is the peptide toxin streptolysin S (SLS). In addition to its well-recognized role as a cytolysin,(More)
Peptides are defined as short chains of amino acids that are linked by peptide bonds. In eukaryotes, peptides encompass an enormous range of structure and function, from signaling hormones, to anti-pathogen molecules, to powerful toxins. In bacteria, ribosomally produced peptides known as bacteriocins have been historically investigated for their potential(More)
Many bacterial pathogens secrete potent toxins to aid in the destruction of host tissue, to initiate signaling changes in host cells or to manipulate immune system responses during the course of infection. Though methods have been developed to successfully purify and produce many of these important virulence factors, there are still many bacterial toxins(More)
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