Raymond Sandler

Learn More
One of the links in the trisynaptic circuit of the hippocampus is the synapse between the mossy fibre terminals of dentate granule cells and CA3 pyramidal cells of Ammon's horn. This synapse has been physiologically characterized as excitatory, and there is pharmacological and immunohistochemical evidence that mossy fibre terminals utilize glutamate as a(More)
Epidemiological and experimental evidence indicates that consumption of fried meats in conjunction with certain genotypes of phase I and II metabolism genes poses an elevated risk for colorectal cancer. Parallel to this, the consumption of cruciferous vegetables is associated with a reduced risk of colon cancer. Therefore, we designed a 6-week pilot feeding(More)
  • R Sandler
  • 1976
A 56-year-old woman presented in 1973 with hyperthyroidism and partial anterior pituitary insufficiency. Three years before she had undergone pituitary irradiation for acromegaly and hyperthyroidism, the latter was attributed at the time to excessive TSH secretion because of elevations in plasma TSH. During the present 11/2 years of observation, TSH levels(More)
Described here is a patient with insulin-requiring diabetes mellitus in whom spontaneous fasting hypoglycemia developed. Endogenous hyperinsulinism was considered after the systematic exclusion of other causes of hypoglycemia, and this possibility was confirmed by measurement of serum C-peptide reactivity (CPR), an indicator of beta cell secretory function.(More)
A hormonally active oxyphil adenoma of the parathyroid masqueraded as a thyroid nodule and was present as a palpable neck mass for more than six years prior to the onset of clinically obvious hyperparathyroidism. The slow evolution of the hyperparathyroidism in the presence of a relatively large adenoma was correlated with the presumptive low hormonal(More)