Raymond S.H. Yang

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BACKGROUND Quantum dots (QDs) are autofluorescent semiconductor nanocrystals that can be used for in vivo biomedical imaging. However, we know little about their in vivo disposition and health consequences. OBJECTIVES We assessed the tissue disposition and pharmacokinetics of QD705 in mice. METHODS We determined quantitatively the blood and tissue(More)
BACKGROUND One problem of interpreting population-based biomonitoring data is the reconstruction of corresponding external exposure in cases where no such data are available. OBJECTIVES We demonstrate the use of a computational framework that integrates physiologically based pharmacokinetic (PBPK) modeling, Bayesian inference, and Markov chain Monte Carlo(More)
  • Thomas J Mackin, Steven C Noe, K J Ball, B C Bedell, D P Bim-Merle, M C Bingaman +37 others
  • 2000
Disc brakes are exposed to large thermal stresses during routine braking and extraordinary thermal stresses during hard braking. High-g decelerations typical of passenger vehicles are known to generate temperatures as high as 900 C in a fraction of a second. These large temperature excursions have two possible outcomes: thermal shock that generates surface(More)
BACKGROUND One of the most serious human health concerns related to environmental contamination with polychlorinated biphenyls (PCBs) is the presence of these chemicals in breast milk. OBJECTIVES We developed a physiologically based pharmacokinetic model of PCB-153 in women, and predict its transfer via lactation to infants. The model is the first human,(More)
Fish and shellfish caught in polluted waters contain potentially dangerous amounts of toxic and carcinogenic chemicals. Public concern was heightened when a large percentage of winter flounder taken from Boston Harbor was found to have visible cancer of the liver; winter flounder outside the estuary area had no liver lesions. Long-term chemical(More)
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