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CONTEXT
Women have a higher incidence of torsades de pointes than men, but it is not known if the risk of drug-induced torsades de pointes varies during the menstrual cycle.
OBJECTIVES
To determine… (More)
- Donald Peter Robertson, Darryl Wade, Robert Workman, Raymond L Woosley, John A. Oates
- The Journal of clinical investigation
- 1981
Acute caffeine in subjects who do not normally ingest methylxanthines leads to increases in blood pressure, heart rate, plasma epinephrine, plasma norepinephrine, plasma renin activity, and urinary… (More)
- Xingfei Liu, Alexander N Katchman, Steven N Ebert, Raymond L Woosley
- The Journal of pharmacology and experimental…
- 1998
Tamoxifen is an antiestrogen drug commonly used to treat breast cancer and has been shown to cause prolongation of the electrocardiographic QT interval in humans. Because QT prolongation could… (More)
- Tal Lorberbaum, Kevin J. Sampson, +4 authors Nicholas P. Tatonetti
- Journal of the American College of Cardiology
- 2016
BACKGROUND
QT interval-prolonging drug-drug interactions (QT-DDIs) may increase the risk of life-threatening arrhythmia. Despite guidelines for testing from regulatory agencies, these interactions… (More)
- Raymond L Woosley
- Annual review of pharmacology and toxicology
- 1996
Two of the nonsedating antihistaminic drugs, terfenadine and astemizole, have recently been recognized in rare cases to induce the syndrome of torsades de pointes, i.e. QT interval prolongation and… (More)
- Dan M. Roden, Raymond L Woosley, R. K. Primm
- American heart journal
- 1986
Quinidine therapy is one of the most common causes of the acquired long QT syndrome and torsade de pointes. In reviewing clinical data in 24 patients with the quinidine-associated long QT syndrome,… (More)
- Lesley H. Curtis, Truls Østbye, +5 authors Kevin A. Schulman
- Archives of internal medicine
- 2004
BACKGROUND
We sought to determine the extent of potentially inappropriate outpatient prescribing for elderly patients, as defined by the Beers revised list of drugs to be avoided in elderly… (More)
- Ellen C. Pearson, Raymond L Woosley
- Pharmacoepidemiology and drug safety
- 2005
BACKGROUND
Recent case series have associated the synthetic opioid, methadone, with QT prolongation and torsades de pointes (TdP) ventricular arrhythmia.
STUDY OBJECTIVE
To review and analyze… (More)
- Frank Bode, Alexander N Katchman, Raymond L Woosley, Michael R. Franz
- Circulation
- 2000
BACKGROUND
Atrial fibrillation (AF) is frequently associated with atrial dilatation caused by pressure or volume overload. Stretch-activated channels (SACs) have been found in myocardial cells and… (More)
- L A Siddoway, Keith A. Thompson, +4 authors Raymond L Woosley
- Circulation
- 1987
The relationship between debrisoquine metabolic phenotype and the pharmacokinetics and pharmacodynamics of propafenone was studied in 28 patients with chronic ventricular arrhythmias (22 extensive… (More)