BACKGROUND Nearly 50% of patients with heart failure (HF) have preserved LV ejection fraction, with interstitial fibrosis and cardiomyocyte hypertrophy as early manifestations of pressure overload. However, methods to assess both tissue characteristics dynamically and noninvasively with therapy are lacking. We measured the effects of mineralocorticoid… (More)
Unaliasing by Fourier-encoding the overlaps using the temporal dimension (UNFOLD) is a method to reduce the data acquisition burden in dynamic MRI. The method works by forcing aliased signals to behave in specific ways through time, so that these unwanted signals can be detected and removed. Unexpected events in time, such as displacements caused by… (More)
BACKGROUND High reproducibility of LV mass and volume measurement from cine cardiovascular magnetic resonance (CMR) has been shown within single centers. However, the extent to which contours may vary from center to center, due to different training protocols, is unknown. We aimed to quantify sources of variation between many centers, and provide a… (More)
Fibrotic burden of LV myocardium quantified by CMR provides additional information about LA size and mechanics than morphological severity of LV hypertro-phy measured by LV mass index alone.
Characterization of subacute and convalescent fibrotic burden in the remote myocardium after acute infarction provides strong and incremental prediction of changes in left and right functions and final infarct size, incremental to knowledge of the subacute infarct size Summary To test the hypothesis that fibrotic burden in remote myocardium quantified by… (More)
Patients with apical hypertrophic cardiomyopathy (APH) have evidence of increased fibrotic burden, compared to normal controls, in myocardial segments without visible LGE. This finding may have diagnostic implication in patients with thickened apical segments of the LV and a clinical suspicion of APH.
CMR quantification of infarct tissue heterogeneity and remote myocardial fibrotic burden during convalescent phase following acute myocardial infarction (MI) provided strong and complementary evidence of ventricular arrhythmogenicity from quantitative microvolt T-wave alternans testing (the NHLBI PROSPECT-CMR study) Summary In patients with recent MI,… (More)