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PURPOSE The target enzyme for 5-fluorouracil (5-FU) is thymidylate synthase (TS). The TYMS gene encoding this enzyme is polymorphic, having either double (2R) or tri-tandem (3R) repeats of a 28-bp sequence in the promoter region and a 6-bp variation in the 3'-untranslated region (3'-UTR). TS expression predicts response to 5-FU-based chemotherapy, and the(More)
BACKGROUND In patients with clinical signs that may indicate a colorectal cancer, physicians may interpret the presence of a comorbid depressive mood as either increasing or decreasing the likelihood of cancer diagnosis. This study examined the association between depressive mood in candidates for a colonoscopy and subsequent diagnosis of cancer. METHODS(More)
Smart manufacturing has increasingly become a prominent research topic across the academia and industry during recent years. However, in the real world, most factories' conditions are normally insufficient for implementing full scale smart manufacturing. In order to increase smartness for manufacturing systems under different situations, one may observe(More)
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