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BACKGROUND & AIMS Methotrexate and infliximab are effective therapies for Crohn's disease (CD). In the combination of maintenance methotrexate-infliximab trial, we evaluated the potential superiority of combination therapy over infliximab alone. METHODS In a 50-week, double-blind, placebo-controlled trial, we compared methotrexate and infliximab with(More)
BACKGROUND The gut microbiota is associated with the modulation of mucosal immunity and the etiology of inflammatory bowel diseases (IBD). Previous studies focused on the impact of bacterial species on IBD but seldom suspected archaea, which can be a major constituent of intestinal microbiota, to be implicated in the diseases. Recent evidence supports that(More)
A 19-year-old man first presented with clinical, radiological, and manometric features of diffuse spasm. Within a year his motility disorder progressed to "vigorous" and, finally, classic achalasia. After pneumatic dilatation and subsequent long myotomy, the features of classic achalasia disappeared and he again exhibited radiological and manometric(More)
We studied the effect of ethanol on glucose and water absorption in vivo. In preliminary experiments, using sodium amytal anesthesia, we found that control animals, whose jejunal segment was perfused without ethanol, required more anesthetic agent than those perfused with ethanol. Thus, to allow for unbiased comparison of the absorption data between the two(More)
The purpose of this study is to assess the ability of the artificial neural network (ANN) models in estimating river ice thickness using easy available climate data. A site specific ANN models were developed for two hydrometric stations at two rivers in Alberta (Canada). The ANN models were found to adequately estimate ice thickness. Ways to improve the(More)
This is a case report of an 80-year-old female with persistent blood loss from what was initially considered to be "hemorrhagic gastritis." Distal gastrectomy showed extensive atheromatous embolism and resultant ischemic lesions of the stomach--the apparent cause of the chronic bleeding. The patient has remained well without further blood loss during a(More)
A case of cholera occurred in Kingston, Ont. in 1974 in a traveller from South Africa. Treatment, based on an understanding of the pathophysiology of cholera diarrhea and the mechanism of action of the Vibrio cholerae enterotoxin on gastrointestinal fluid loss, consisted of correcting the severe loss of fluid and electrolytes and the metabolic acidosis, as(More)
We have investigated the 3-O-methyl-D-glucose (3MG) absorption by jejunal biopsies obtained from a patient with cholera. The absorption of 3MG (as measured from the determination of intracellular accumulation of this sugar) was found to occur against a concentration gradient and to be a saturable process that follows Michaelis-Menten kinetics. There was no(More)