Rayavarapu Bhargavi

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Comparative protein modeling, active site analysis and binding site specificity for the homologous series of plasmepsins (PM's), present in food vacuole of Plasmodium falciparum, are carried out. Four loops (L1, L2, L3 and L4), which show maximum structural deviations irrespective of type of inhibitor, have been identified. Comparison of the crystal(More)
GST (glutathione S-transferases) are a family of detoxification enzymes that catalyze the conjugation of reduced GSH (glutathione) to xenobiotic (endogenous electrophilic) compounds. GST from Wb (Wuchereria bancrofti) and Bm (Brugia malayi) are significantly different from human GST in sequence and structure. Thus, Wb-GST and Bm-GST are potential(More)
A series of Manganese (II) Schiff base complexes were synthesized by microwave irradiation method, the Schiff bases are derived from substituted salicylaldehyde With 1,4-diaminobutane and ophenylnediamine. The manganese complexes were characterized by UV-Visible, Infrared (FT-IR) and Electron Paramagnetic Resonance (EPR) spectroscopic techniques. The(More)
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