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  • A M James Shapiro, Jonathan R. T. Lakey, +5 authors Ray V. Rajotte
  • Medicine
  • The New England journal of medicine
  • 2000 (First Publication: 27 July 2000)
  • BACKGROUND Registry data on patients with type 1 diabetes mellitus who undergo pancreatic islet transplantation indicate that only 8 percent are free of the need for insulin therapy at one year. Continue Reading
  • Gregory S Korbutt, John F Elliott, Ziliang Ao, Diane K. Smith, Garth L. Warnock, Ray V. Rajotte
  • Biology, Medicine
  • The Journal of clinical investigation
  • 1996 (First Publication: 1 May 1996)
  • Based upon existing methods of isolating fetal porcine islet tissue, a simple, reliable procedure was developed for the preparation of porcine neonatal islet cell aggregates with a reproducible andContinue Reading
  • Karen L Seeberger, Jannette M. Dufour, A M James Shapiro, Jonathan R T Lakey, Ray V. Rajotte, Gregory S Korbutt
  • Medicine, Biology
  • Laboratory Investigation
  • 2006 (First Publication: 1 February 2006)
  • Fibroblast-like cells emerging from cultured human pancreatic endocrine and exocrine tissue have been reported. Although a thorough phenotypic characterization of these cells has not yet been carriedContinue Reading
  • Isabelle Leclerc, Wolfram W W Woltersdorf, +6 authors Guy A. Rutter
  • Medicine, Biology
  • American journal of physiology. Endocrinology and…
  • 2004 (First Publication: 1 June 2004)
  • Metformin, a drug widely used in the treatment of type 2 diabetes, has recently been shown to act on skeletal muscle and liver in part through the activation of AMP-activated protein kinase (AMPK).Continue Reading