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Zika virus (ZIKV) is currently undergoing pandemic emergence. While disease is typically subclinical, severe neurologic manifestations in fetuses and newborns after congenital infection underscore an urgent need for antiviral interventions. The adenosine analog BCX4430 has broad-spectrum activity against a wide range of RNA viruses, including potent in vivo(More)
1779. Prevalence of and Factors Associated with Clostridium difficile Co-infection Among Patients with Candidemia, United States, 2014–2016 Sharon Tsay, MD; Kaitlin Benedict, MPH; Zintars G. Beldavs, MS; Monica M. Farley, MD, FIDSA; Lee H. Harrison, MD; William Schaffner, MD, FIDSA, FSHEA; Taryn Gerth, MPH; Tom Chiller, MD, MPH; Snigdha Vallabhaneni, MD,(More)
target amplicons. An in-house ELISA was used to ascertain the presence or absence of serum DENV IgG. Trends were assessed using Jonckheere-Terpstra and Chisquare for proportions tests. The Mann–Whitney-Wilcoxon test was used to compare medians. Linear regression modeling was used to determine the association between DENV IgG and ZIKV VL. Results. Of the 319(More)
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