Ray M. Lowenthal

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We have developed an antibody-based method to assess plasma uptake of a proprietary Undaria-derived fucoidan galactofucan sulfate (GFS(TM)) after oral ingestion by human volunteers. Fucoidans have high-molecular-weights but exert biological effects in experimental animals after oral intake. By using a novel antibody raised against sulfated polysaccharides,(More)
BACKGROUND Previous pooled analyses have reported an association between magnetic fields and childhood leukaemia. We present a pooled analysis based on primary data from studies on residential magnetic fields and childhood leukaemia published after 2000. METHODS Seven studies with a total of 10,865 cases and 12,853 controls were included. The main(More)
There is a wide variety of cancer types yet, all share some common cellular and molecular behaviors. Most of the chemotherapeutic agents used in cancer treatment are designed to target common deregulated mechanisms within cancer cells. Many healthy tissues are also affected by the cytotoxic effects of these chemical agents. Fucoidan, a natural component of(More)
Discussion Carbenicillin is an established antibiotic for infections due to two difficult groups of organisms-Ps. aeruginosa and the indole-positive Proteus spp.4 Non-,3-lactamase-producing E. coli are very susceptible to carbenicillin and Str. faecalis moderately so. Though carbenicillin is particularly useful against Ps. aeruginosa high parenteral doses(More)
BACKGROUND Bevacizumab is an antiangiogenic mAb with efficacy against several cancers, but it is associated with risk of arterial thromboembolism (ATE). Further data are needed to determine the safety of bevacizumab. PATIENTS AND METHODS We recorded grade 3, 4, or 5 ATE events and other data (including age, baseline cardiovascular risk factors, history of(More)
During the final correction of the above paper prior to its publication in late 2010, an error was introduced in Table 4. In the third line, under the subheading 'Measurement studies', the category should read 'Current update without Brazil'. The correct Table is now shown, below. The publishers apologise for this mistake. Table 4 Comparison of summary odds(More)
Is there a role for brown macroalgae-derived fucoidan in cancer therapeutics? This review discusses the in vitro, in vivo and clinical data concerning fucoidan and cancer. Fucoidans vary according to the species from which they are derived, making direct comparisons between studies difficult. Data from in vitro studies indicate direct activity against some(More)
By use of the continuous-flow blood-cell separator 137 bags of granulocyte-rich plasma were obtained from normal donors (59 bags) and patients with chronic granulocytic leukaemia (C.G.L.) (78 bags). Eighty-nine courses of granulocyte transfusion therapy consisting of 1 or more such bags were administered to forty-one ABO-compatible patients with acute(More)
Extracranial metastases of glioblastoma multiforme (GBM) are rare and usually occur in the context of recurrent intracranial GBM. We present a 39-year-old man with histologically confirmed GBM. The patient remained well for nearly 2 years, with no signs of recurrent tumour. He then presented with distant recurrence within the brain at the same time as(More)
Complications of bone marrow trephine are thought to be uncommon. Herein, we present a case of severe debilitating sciatic nerve palsy secondary to a gluteal artery pseudoaneurysm following bone marrow biopsy. The pseudoaneurysm was treated successfully by percutaneous embolization; however, the patient remains significantly impaired with persistent(More)