Ray-Jade Chen

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This study presents a novel wireless, ambulatory, real-time, and autoalarm intelligent telecardiology system to improve healthcare for cardiovascular disease, which is one of the most prevalent and costly health problems in the world. This system consists of a lightweight and power-saving wireless ECG device equipped with a built-in automatic warning expert(More)
A multi-functional cardiac signal processor (CSP) with integrated sensor interfaces is designed for mobile healthcare applications, especially for heart activity diagnosis in different phases. Applying dedicated processing engines, the CSP extracts critical cardiac signal features based on compressed data with 90% storage reduction, while keeping the data(More)
—This work presents a biomedical signal processor (BSP) with hybrid functional cores to optimize the power dissipation and system flexibility for mobile healthcare applications. Embedded with the biomedical core and a 32-bit RISC core, multi-features are extracted for classification and the abnormal data are compressed. In addition, the crypto core secures(More)
BACKGROUND Tumor necrosis factor (TNF)-α and matrix metalloproteinases (MMPs) are elevated in pleural fluids of tuberculous pleuritis (TBP) where pleural mesothelial cells (PMCs) conduct the first-line defense against Mycobacterium tuberculosis (MTB). However, the clinical implication of TNF-α and MMPs in TBP and the response of PMCs to MTB infection remain(More)
The objective of this study is to evaluate the efficacy and safety profiles of the targeted medications, bevacizumab and cetuximab, in combination with cytostatic drugs in patients with locally advanced or metastatic pancreatic cancer. In this retrospective phase 2 study, a total of 59 patients with pancreatic cancer were recruited and received conventional(More)
Aging is the most important risk factor in cardiovascular disease (CVD), which is the leading causes of death worldwide and the second major cause of death in Taiwan. The major factor in heart failure during aging is heart remodeling, including long-term stress-induced cardiac hypertrophy and fibrosis. Exercise is good for aging heart health, but the impact(More)
Obesity is one of the major risk factors for nonalcoholic fatty liver disease (NAFLD), and NAFLD is highly associated with an increased risk of cardiovascular disease (CVD). Scholars have suggested that certain probiotics may significantly impact cardiovascular health, particularly certain Lactobacillus species, such as Lactobacillus reuteri GMNL-263(More)
Current chemotherapeutic regimens for nonsmall cell lung cancer (NSCLC) have reached a plateau over the last few years. Targeted therapy makes use of tyrosine kinase inhibitors (TKIs) to suppress a number of signaling pathways including epidermal growth factor receptor and vascular endothelial growth factor which are active in NSCLC biology. In this study,(More)
The spleen is the most vulnerable visceral organ involved in blunt abdominal trauma; 40% to 70% of patients with blunt splenic laceration can be managed with nonsurgical methods. A majority of hematomas of the spleen can heal and be absorbed within 2 to 3 months; through an unknown mechanism in an unusual condition, the hematoma may organize and eventually(More)
BACKGROUND It is known that the medicinal herb Alpinia oxyphylla Miq. is widely used as a remedy for diarrhea as well as the symptoms accompanying hypertension and cerebrovascular disorders. Moreover, it has also been reported that Alpinia oxyphylla Miq. has beneficial effects on anti-senescence and neuro-protection. This study focuses on the molecular(More)