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  • Ray Dolin
  • Infectious disease clinics of North America
  • 2000
Phase I and II studies have been carried out with several candidate HIV-1 vaccines in seronegative volunteers. Vaccines consisting of rgp 120 stimulated moderate levels of neutralizing antibodies against homologous, TCLA adapted viruses, but did not induce CD8+ CTL responses. Canarypox vectors stimulate CD8+ CTL responses, but little neutralizing activity.(More)
Antiviral compounds have been developed for use in chemoprophylaxis and chemotherapy of a variety of infections in humans, including those caused by influenza viruses, respiratory syncytial virus, and herpesviruses. The efficacy of several of these compounds has been demonstrated in rigorously controlled trials. Advances in molecular virology have led to(More)
Executive Summary The related areas of chemical biology, pharmacology, and therapeutics afford enormous opportunities for innovation in education, research, and treatment of disease. There are major strengths in these areas at Harvard on which to build, particularly in basic biology and clinical research, and pockets of strength in therapeutically relevant(More)
  • Ray Dolin
  • Journal of the American Veterinary Medical…
  • 1978
Currently, 6 agents of viral gastroenteritis with properties similar to the Norwalk agent have been described. These are the Hawaii, Montgomery County, W, Ditchling, and Cockle agents, as well as the Norwalk agent. These agents are 25 to 27 nm in diameter, are nonenveloped, and have a buoyant density of 1.38 to 1.40 g/cc in CsCl. Multiple antigenic types(More)
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