Sort by:

• Highly Influential Citations
• Citations
• Acceleration
• Velocity
• Recency

Learn More

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

• Zheng Sun, Russell A. Miller, +12 authors Mitchell A Lazar
• Nature Medicine
• 2012

Fatty liver disease is associated with obesity and type 2 diabetes, and hepatic lipid accumulation may contribute to insulin resistance. Histone deacetylase 3 (Hdac3) controls the circadian rhythm of… (More)

Sexually dimorphic regulation of hepatic isoforms of human cytochrome p450 by growth hormone.

• Ravindra N. Dhir, Wojciech Dworakowski, Chellappagounder Thangavel, Bernard H. Shapiro
• The Journal of pharmacology and experimental…
• 2006

Sex differences in drug metabolism have been reported in numerous species, including humans. In rats and mice, sex-dependent differences in circulating growth hormone profiles are responsible for the… (More)

Interpulse growth hormone secretion in the episodic plasma profile causes the sex reversal of cytochrome P450s in senescent male rats.

• Ravindra N. Dhir, Bernard H. Shapiro
• Proceedings of the National Academy of Sciences…
• 2003

Humans as well as other mammals experience an aging-related decline in drug metabolism as well as a diminution in growth hormone secretion. In the case of rats, these events are more pronounced in… (More)

Inhibition of ADRP prevents diet-induced insulin resistance.

• Gladys M Varela, Daniel Ansong Antwi, +5 authors Rexford S. Ahima
• American journal of physiology. Gastrointestinal…
• 2008

Diets with high fat content induce steatosis, insulin resistance, and type 2 diabetes. The lipid droplet protein adipose differentiation-related protein (ADRP) mediates hepatic steatosis, but whether… (More)

The effects of a soluble activin type IIB receptor on obesity and insulin sensitivity

• Imo J Akpan, Marcus D. Goncalves, +7 authors Rexford S. Ahima
• International Journal of Obesity
• 2009

Background:Myostatin, also known as Growth and Differentiation Factor 8, is a secreted protein that inhibits muscle growth. Disruption of myostatin signaling increases muscle mass and decreases… (More)

Inadequacy of the Janus kinase 2/signal transducer and activator of transcription signal transduction pathway to mediate episodic growth hormone-dependent regulation of hepatic CYP2C11.

• Ashish S. Verma, Ravindra N. Dhir, Bernard H. Shapiro
• Molecular pharmacology
• 2005

CYP2C11, the most commonly expressed hepatic cytochrome P450 isoform in male rats, is induced by the masculine "episodic" secretory growth hormone profile. A considerable number of reports have… (More)

Attenuated expression of episodic growth hormone-induced CYP2C11 in female rats associated with suboptimal activation of the Jak2/Stat5B and other modulating signaling pathways.

• Ravindra N. Dhir, Chellappagounder Thangavel, Bernard H. Shapiro
• Drug metabolism and disposition: the biological…
• 2007

Inherent sex differences in various parameters of growth, musculoskeletal function, metabolism, and cytochrome P450 (P450)-dependent drug metabolism have been reported in rats and humans administered… (More)

Prevention of latently expressed CYP2C11, CYP3A2, and growth hormone defects in neonatally monosodium glutamate-treated male rats by the N-methyl-D-aspartate receptor antagonist dizocilpine maleate.

• Antje Kaufhold, Prabhat Kumar Nigam, Ravindra N. Dhir, Bernard H. Shapiro
• The Journal of pharmacology and experimental…
• 2002

Neonatal administration of monosodium glutamate (MSG) can produce latently expressed defects in drug metabolism and growth hormone secretion as well as stunted growth and obesity. Instead of… (More)

Estrogen sulfotransferase regulates body fat and glucose homeostasis in female mice.

• Victor K Khor, Ravindra N. Dhir, Xiaoyan Yin, Rexford S. Ahima, Wen-chao Song
• American journal of physiology. Endocrinology and…
• 2010

Estrogen regulates fat mass and distribution and glucose metabolism. We have previously found that estrogen sulfotransferase (EST), which inactivates estrogen through sulfoconjugation, was highly… (More)

Middle-age alterations in the sexually dimorphic plasma growth hormone profiles: involvement of growth hormone-releasing factor and effects on cytochrome p450 expression.

• Ravindra N. Dhir, Wojciech Dworakowski, Bernard H. Shapiro
• Drug metabolism and disposition: the biological…
• 2002

Rat liver, as well as other species, contains numerous sex-dependent isoforms of cytochrome P450 (P450) that are regulated by the sexually dimorphic profiles of circulating growth hormone. During… (More)

• ‹
• 1
• 2
• ›