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OBJECTIVE The aim of this study was to assess the relationship between receipt of routine childhood immunizations and infant mortality before 6 months of age. METHODS This was an observational study of 10,274 infants, in a randomized trial of vitamin A supplementation, who received the study dose and survived to at least 1 week of age. The primary outcome(More)
OBJECTIVE To assess the impact of supplementing newborn infants with vitamin A on mortality at age 6 months. DESIGN Community based, randomised, double blind, placebo controlled trial. SETTING Two rural districts of Tamil Nadu, southern India. PARTICIPANTS 11 619 newborn infants allocated 24 000 IU oral vitamin A or placebo on days 1 and 2 after(More)
BACKGROUND Exposure to indoor air pollution due to open burning of biomass fuel is common in low- and middle-income countries. Previous studies linked this exposure to an increased risk of respiratory illness, low birth weight (LBW) and other disorders. We assessed the association between exposure to biomass fuel sources and second-hand tobacco smoke (SHTS)(More)
OBJECTIVE To determine the prevalence of blindness and vision impairment in a rural population of southern India. DESIGN A population-based cross-sectional study. PARTICIPANTS A total of 17200 subjects aged 6 years or older, including 5150 subjects aged 40 years or older from 50 clusters representative of three southern districts of Tamil Nadu in(More)
AIMS To assess the prevalence of vision impairment, blindness, and cataract surgery and to evaluate visual acuity outcomes after cataract surgery in a south Indian population. METHODS Cluster sampling was used to randomly select a cross sectional sample of people > or =50 years of age living in the Tirunelveli district of south India. Eligible subjects in(More)
PURPOSE To determine the prevalence and risk factors for pseudoexfoliation in a rural population of southern India. DESIGN A population-based cross-sectional study of pseudoexfoliation with and without glaucoma in rural southern India. METHOD A total of 5,150 subjects aged 40 years and older from 50 clusters representative of three southern districts of(More)
OBJECTIVE To determine the magnitude of vitreoretinal disorders in a rural southern Indian population. METHODS Cluster sampling was used to identify individuals 40 years and older in Tamil Nadu in southern India. Demographic details, vision measurement and refraction using logMAR charts, anterior segment slitlamp examination, dilated posterior segment(More)
A random sample of mothers living in two neighbourhoods of a southern Indian city were interviewed in order to determine the prevalence of serious disability in children 2-9 years old. These areas were selected because residents constitute either the lowest class or the next higher socioeconomic class (next-to-lowest class), with monthly incomes of US$(More)
BACKGROUND Clinical vitamin A deficiency affects millions of children worldwide, and subclinical deficiency is even more common. Supplemental vitamin A has been reported to reduce mortality among these children, but the results have been questioned. METHODS We conducted a randomized, controlled, masked clinical trial for one year in southern India(More)
Incidence, duration, and severity of diarrhea and respiratory symptoms were monitored weekly for 1 y in 15,419 children 6-60 mo of age in a randomized, placebo-controlled, masked clinical trial conducted in southern India. Half the children received weekly doses of 8.7 mumol (2500 microgram) vitamin A and 46 mumol (20 mg) vitamin E (treated) and the other(More)