Ravil Abdryashitov

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Induction of a cyclin-dependent kinase inhibitor p21Waf1/Cip1/Sdi1 is an integral part of cell growth arrest associated with senescence and damage response. p21 overexpression from an inducible promoter resulted in senescence-like growth arrest in a human fibrosarcoma cell line. After release from p21-induced growth arrest, cells re-entered the cell cycle(More)
Arrestin proteins play a key role in the desensitization of G protein-coupled receptors (GPCRs). Recently we proposed a molecular mechanism whereby arrestin preferentially binds to the activated and phosphorylated form of its cognate GPCR. To test the model, we introduced two different types of mutations into beta-arrestin that were expected to disrupt two(More)
The FLT4/VEGFR3 tyrosine kinase receptor belongs to a class of receptors for growth factors of the vascular endothelial growth factor family and is important for the biology of lymphatic endothelium. It may play an important role in tumor growth. We have looked for the expression of the FLT4 gene in tumors of various origins. FLT4 expression was not found(More)
i. N. N. Brustovetskii, V. G. Gogvadze, and E. I. Maevskii, Biol. Nauki, No. 4, 14 (1988). 2. Yu. A. Vladimirov and G. E. Dobretsov, Fluorescent Probes in the Study of Biological Membranes [in Russian], Moscow (1980). 3. V. G. Ivkov and G. N. Berestovskii, Dynamic Structure of the Lipid Bilayer [in Russian], Moscow (1981). 4. I. V. Zhigacheva, A. I.(More)
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