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- Publications
- Influence
Pharmacological and pharmacokinetic evaluation of celecoxib prodrugs in rats
- Rao N.V.S. Mamidi, R. Mullangi, +9 authors R. Rajagopalan
- Medicine, Chemistry
- Biopharmaceutics & drug disposition
- 1 October 2002
This study demonstrates the utility of an in vitro – in vivo correlative approach in the selection and optimization of a prodrug candidate of celecoxib (CBX), a COX2 inhibitor. As an initial… Expand
2-hydroxymethyl-4-[5-(4-methoxyphenyl)-3-trifluoromethyl-1H-1-pyrazolyl]-1-benzenesulfonamide (DRF-4367): an orally active COX-2 inhibitor identified through pharmacophoric modulation.
- S. Singh, Saibaba Vobbalareddy, +9 authors K. R. Yeleswarapu
- Chemistry, Medicine
- Organic & biomolecular chemistry
- 23 August 2004
Analogs of 1,5-diarylpyrazoles with a novel pharmacophore at N1 were designed, synthesized and evaluated for the in-vitro cyclooxygenase (COX-1/COX-2) inhibitory activity. The variations at/around… Expand
Assessing the issue of instability due to Michael adduct formation in novel chemical entities possessing a carbon-carbon double bond during early drug development--applicability of common laboratory…
- Akshanth Reddy Polepally, V. Kumar, +7 authors N. Srinivas
- Chemistry, Medicine
- Biomedical chromatography : BMC
- 1 September 2008
The discovery of small-molecule novel chemical entities (NCEs) is often a complex play between appropriate structural requirements and optimization of the desired efficacy, safety and pharmacokinetic… Expand
Assessment of oral bioavailability and preclinical pharmacokinetics of DRF-6196, a novel oxazolidinone analogue, in comparison to linezolid®
- Ravikanth Bhamidipati, P. Venkatesh, +5 authors N. R. Srinivas
- Medicine
- European Journal of Drug Metabolism and…
- 1 July 2005
SummaryThe aim of this study was to determine the bioavailability of a novel oxazolidinone, DRF-6196, in mice and rats followingintravenous (i.v) and oral dosing and to compare the pharmacokinetics… Expand