Ravi Sudesh

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BACKGROUND Breast cancer, the commonest cancer among women in the world, ranks top in India with an incidence rate of 1,45,000 new cases and mortality rate of 70,000 women every year. Chemotherapy outcome for breast cancer is hampered due to poor response and irreversible dose-dependent cardiotoxicity which is determined by genetic variations in drug(More)
Human Pregnane X Receptor (also called NR1I2), a member of orphan nuclear receptor superfamily, maps to chromosome 3q11-13 with ten exons coding for 434 amino acids (Zhang et al., 2001). PXR is a xenobiotic sensor and acts as a transcription factor of drug metabolizing enzymes (DMEs) and drug transporters. It can potentially affect the efficacy of(More)
Schizophrenia (SCZ) as a severe and complex neuropsychiatric disorder and is characterized by positive symptoms, negative symptoms and cognitive dysfunctions. Genome-wide association studies (GWAS) have identified a strong association between the single nucleotide polymorphism (SNP) rs12807809 upstream of Neurogranin (NRGN) in a European population. This(More)
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