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Ephrins and Eph receptor tyrosine kinases are cell-surface molecules that serve a multitude of functions in cell-cell communication in development, physiology, and disease. EphA4 is a promiscuous member of the EphA subclass of Eph receptors and can bind to both EphrinAs and EphrinBs. In addition to its well-established roles in guiding the development of(More)
One important aspect of recovery and repair after spinal cord injury (SCI) lies in the complex cellular interactions at the injury site that leads to the formation of a lesion scar. EphA4, a promiscuous member of the EphA family of repulsive axon guidance receptors, is expressed by multiple cell types in the injured spinal cord, including astrocytes and(More)
Background Somatic embryogenesis (SE) technology is expected to play a significant role in future forest tree improvement programs. Methods for efficient SE propagation in soft-wood species based on bioreactors are underway [1]. Furthermore, genetic transformation through SE is also the most promising approach to generate and propagate elite recalcitrant(More)
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