Ravi Seshadri

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Methods to detect and quantify minimal residual disease (MRD) after chemotherapy for acute lymphoblastic leukaemia (ALL) could improve treatment by identifying patients who need more or less intensive therapy. We have used a clone-specific polymerase chain reaction to detect rearranged immunoglobulin heavy-chain gene from the leukaemic clone, and quantified(More)
Both growth factors and steroid hormones are known to be associated with breast cancer. We have studied the epidermal growth factor receptor (EGFR) in canine mammary tumors and have shown the presence of a single class of 125I-EGF binding receptor sites in 9 out of 13 (70%) tumors, using Scatchard plot. The dissociation constant (KD) was 10(-9)M. An inverse(More)
To assess the long-term effects of cancer treatment and consequences of cure, 102 index cancer cases were compared with 95 neighbourhood controls of similar age and sex and with 78 cardiac controls. The quality of life experienced by these three groups was examined using multiple instruments with proven psychometric properties. All the major quality of life(More)
N-Benzyladriamycin-14-valerate (AD198) is a novel lipophilic anthracycline with greater in vivo antitumour activity than doxorubicin (DOX) in experimental model systems. Using sensitive and progressively DOX-resistant L1210 mouse leukaemia and B16-BL6 mouse melanoma lines, we have determined the cellular pharmacokinetics and cytotoxic response in vitro and(More)
With the ever-increasing cost for healthcare and increased health insurance premiums, there is a need for proactive healthcare and wellness. In addition, the new wave of digitizing medical records has seen a paradigm shift in the healthcare industry. As a result, the healthcare industry is witnessing an increase in sheer volume of data in terms of(More)
The use of fine needle aspiration (FNA) cytology in the management of patients with lymphadenopathy was investigated. The cases of non-Hodgkin's lymphoma were classified using the Kiel classification, which is based strictly on cytological criteria. Of the 59 cases of biopsy confirmed lymphoma, FNA of nodes showed lymphoma in 53 (90%), no definite diagnosis(More)
The tumorigenic properties of human rheumatoid arthritis synovial cells in culture were investigated. The synovial cells developed good colonies and secreted plasminogen activator (PA) and collagenase in the cell cultures, as do Hela cells. Since PA and progesterone receptor (PgR) are considered to be end products of estradiol action in breast cancer cells,(More)
PA and PgR appear to be reliable markers of estradiol action in normal female rat mammary glands, as seen by simultaneous expression of both proteins between the ages of 61 and 131 days. However, expression of PA at certain periods, when PgR was undetectable suggests, that the extent of availability of both estradiol and progesterone at target sites may act(More)