Ravi Mishra

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Abnormal transport of C-terminally truncated prion protein (PrP) to the nucleus has been reported in cell models of familial prion disorders associated with a stop codon mutation at residues 145 or 160 of the PrP. In both cases, PrP is translocated to the nucleus in an energy-dependent fashion, implying the presence of cryptic nuclear localization signal(s)(More)
Familial prion disorders are believed to result from spontaneous conversion of mutant prion protein (PrPM) to the pathogenic isoform (PrPSc). While most familial cases are heterozygous and thus express the normal (PrPC) and mutant alleles of PrP, the role of PrPC in the pathogenic process is unclear. Plaques from affected cases reveal a heterogeneous(More)
Foodborne transmission of bovine spongiform encephalopathy (BSE) to humans as variant Creutzfeldt-Jakob disease (CJD) has affected over 100 individuals, and probably millions of others have been exposed to BSE-contaminated food substances. Despite these obvious public health concerns, surprisingly little is known about the mechanism by which PrP-scrapie(More)
Supplemental ReSultS Quantification of the association of ipla 2 b with the plasma membrane In the absence of MCP-1, only 4% of iPLA 2 b was associated with the peripheral cell membrane of polar, randomly migrating cells. In contrast, MCP-1 induced a statistically significant increase in the association of iPLA 2 b with the cell membrane. Interestingly ,(More)
In this paper we have developed an integrated wireless SCADA system for monitoring & accessing the performance of remotely situated device parameter such as temperature, pressure, humidity on real time basis. For this we have used the infrastructure of the existing mobile network, which is based on GPRS technique Supervisory Control and Data Acquisition(More)
IFN-y is a lymphokine synthesized and secreted by stimulated T lymphocytes. One of the important functions of IFN-y is the activation of mononuclear phagocytes so that they are capable of killing a wide spectrum of intracellular pathogens (reviewed in reference 1). This process requires from 24 to 48 h and is associated with the enhanced production of(More)
  • Megha Gupta, Rajesh Nema, Shankar Ravi, Puran Mishra, Gour, International +2 others
  • 2011
In this paper Bit Error Rate performance of OFDM-BPSK, QPSK, 4-QAM, 16-QAM System over Rayleigh fading channel is analyzed. OFDM is a orthogonal frequency division multiplexing to reduce inter-symbol interference problem. Two of the most equalization algorithms are minimum mean square error (MMSE) equalizer and maximum likelihood sequence estimation (MLSE)(More)
We have analyzed the nature and kinetics of a delayed, cell-mediated immune response to a purified protein derivative of tuberculin (PPD) in the skin of 154 naturally sensitized patients with lepromatous leprosy. After the intradermal injection of 5 U of PPD, biopsies were taken at 1-21 d and studied for the composition, extent, persistence, and(More)
— This paper describes thermal modeling of Vapor Compression Refrigeration System using R134a in primary circuit and AL2O3-Water based nanofluids in secondary circuit. The model uses information of the secondary fluids input conditions geometric characteristics of the system, size of nanoparticles and the compressor speed to predict the secondary fluids(More)
Segmentation of an optic disk location is a very essential task for retinal image analysis. Most of the pervious method uses the principal component analysis method, which are computationally complex. This paper presents a simple and semi automatic approach for segmentation of the optic disc in retinal images using thresholding and boundary extraction.(More)