Ravi Apte

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PURPOSE To study the effect of aqueous humor (AH)-mediated inhibition of natural killer (NK) cell activity on intraocular tumor progression. METHODS Two NK-sensitive tumors, RMA-S lymphoma and OCM-3 uveal melanoma, were tested in vitro for susceptibility to NK cell-mediated lysis in the presence or absence of AH in conventional cytotoxicity assays.(More)
PURPOSE To examine the effect of anti-LFA-1 and anti-ICAM-1 antibody treatment on orthotopic corneal graft survival in a mouse model. METHODS Anti-LFA-1 and anti-ICAM-1 antibodies were administered intraperitoneally before and shortly after orthotopic corneal transplantation. Grafts were observed by biomicroscopy, and survival times were determined.(More)
PURPOSE This study examined the effect of an angiostatic agent on the growth of a highly vascularized intraocular tumor. METHODS A murine uveal melanoma cell line (99E1) was transplanted intracamerally into athymic nude BALB/c mice. Mice were treated topically three times per day beginning on the day of tumor transplantation and continuing through day 28.(More)
This paper describes an integrated pair of tools - one designed for Timing Verification and the other designed for Logic Simulation - in a multi-level, mixed mode description environment. Historically, Logic Simulators and Timing Verifiers have been used for different types of verification, due to an inherent weakness in each. Particularly, Logic simulators(More)
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