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Estrogen replacement increases both the number of dendritic spines and the density of axospinous synapses in the hippocampal CA1 region in young rats, yet this is attenuated in aged rats. The estrogen receptor-alpha (ER-alpha) is localized within select spines of CA1 pyramidal cells in young animals and thus may be involved locally in this process. The(More)
In recent years, several mouse models of amyotrophic lateral sclerosis (ALS) have been developed. One, caused by a G86R mutation in the superoxide dismutase-1 (SOD-1) gene associated with familial ALS, has been subjected to extensive quantitative analyses in the spinal cord. However, the human form of ALS includes pathology elsewhere in the nervous system.(More)
Estrogen regulates hippocampal dendritic spine density and synapse number in an N-methyl-D-aspartate (NMDA) receptor-dependent manner, and these effects may be of particular importance in the context of age-related changes in endocrine status. We investigated estrogen's effects on axospinous synapse density and the synaptic distribution of the NMDA receptor(More)
Estrogen interacts with N-methyl-D-aspartate (NMDA) receptors to regulate multiple aspects of morphological and functional plasticity. In hippocampus, estrogen increases both dendritic spine density and synapse number, and NMDA antagonists block these effects. Thus, estrogen-mediated hippocampal plasticity may be of particular importance in the context of(More)
A further investigation of the importance of pain cognition and behaviour in pain rehabilitation: longitudinal data suggest disability and fear of movement are most important. adults: subjects with healthy backs compared with subjects with low back dysfunction. adults: subjects with healthy backs compared with subjects with low back dysfunction. Kvåle, A.(More)
This paper investigates the influence of slip condition on unsteady magnetohydrodynamics (MHD) thin film flow of an incompressible third grade fluid with temperature dependent viscosity. Both cases of lift and drainage problems are considered. The problem is modeled in terms of non-linear partial differential equations with some physical initial and(More)
  • Bin Raja, Ahsan Shah, Raja Mazuir, Andrew Mcgordon, Amor-Segan, Mark +6 others
  • 2013
(2013) Micro gas turbine range extender : validation techniques for automotive applications. Copyright and reuse: The Warwick Research Archive Portal (WRAP) makes this work by researchers of the University of Warwick available open access under the following conditions. Copyright © and all moral rights to the version of the paper presented here belong to(More)
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