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NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis
This review will provide a brief overview of lipid peroxidation, as well as key components involved in the ferroptotic cascade, focusing on established NRF2 target genes that mitigate these pathways, and the relevance of theNRF2-lipid per oxidation-ferroptosis axis in disease. Expand
Kynurenine pathway, NAD+ synthesis, and mitochondrial function: Targeting tryptophan metabolism to promote longevity and healthspan
How mitochondrial morphological changes and dynamics operate during aging are discussed, and how altered metabolism of tryptophan to NAD+ through the kynurenine pathway interacts with these processes. Expand
Low‐level arsenic causes proteotoxic stress and not oxidative stress
This study challenges the existing paradigm that oxidative stress is the main underlying cause of pathologies associated with environmental arsenic exposure, and indicates that restoring the autophagy pathway and proper proteostasis could be a viable option for treating arsenic‐linked diseases. Expand
Breast tumor stiffness instructs bone metastasis via mechanical memory
It is shown that primary tumor stiffness promotes stable, non-genetically heritable phenotypes in breast cancer cells, and the findings detailing the influence of biomechanical properties support a generalized model of cancer progression in which the integrated properties of the primary tumor microenvironment govern the secondary tumor micro environment, i.e., soil instructs soil. Expand
Abstract LB-241: Kynurenine metabolism as a biomarker and therapeutic target in hepatocellular carcinoma (HCC)
Background: Hepatocellular carcinoma (HCC) is the most prevalent cancer in the liver, the 5th more common cause of deaths by cancer in the US, and the 3th worldwide. Tumor heterogeneity, few targetedExpand
3-hydroxyanthranilic acid – a new metabolite for healthy lifespan extension
It is reported that knockdown of haao-1, a fourth kynurenine pathway gene encoding the enzyme 3-hydroxyanthranilic acid dioxygenase (HAAO), extends lifespan by ~30% and delays age-associated decline in health in Caenorhabditis elegans and identifies HAAO and 3HAA as novel therapeutic targets for age- associated disease. Expand
Inhibition of Kynurenine Metabolism and Its Effect in Mitochondrial Function in Hepatocellular Carcinoma
Abstract Hepatocellular carcinoma (HCC) is the most prevalent cancer in the liver. The majority of ingested tryptophan is processed in the liver through the kynurenine pathway, the endpoint of whichExpand