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Multiple sclerosis (MS) damages central white matter pathways which has considerable impact on disease-related disability. To identify disease-related alterations in anatomical connectivity, 34 patients (19 with relapsing remitting MS (RR-MS), 15 with secondary progressive MS (SP-MS) and 20 healthy subjects underwent diffusion magnetic resonance imaging(More)
Heme, iron (Fe) protoporphyrin IX, functions as a prosthetic group in a range of hemoproteins essential to support life under aerobic conditions. The Fe contained within the prosthetic heme groups of these hemoproteins can catalyze the production of reactive oxygen species. Presumably for this reason, heme must be sequestered within those hemoproteins,(More)
AIMS The aim was to demonstrate a method for automated image analysis of immunohistochemically stained tissue samples for extracting features that correlate with patient disease. We address the problem of quantifying tumor tissue and segmenting and counting cell nuclei. MATERIALS AND METHODS Our method utilizes a flexible segmentation method based on(More)
 Abstract — Motion correction (MC) in positron emission tomography (PET) brain imaging become of higher importance with increasing scanner resolution. Several motion correction methods have been suggested and so far the Polaris Vicra tracking system has been the preferred one for motion registration. We present an automated algorithm for dividing PET(More)
BACKGROUND The beneficial effects of testosterone treatment (TT) are debated. METHODS Double-blinded, placebo-controlled study of six months TT (gel) in 54 men aged 60-78 with bioavailable testosterone (BioT) <7.3 nmol/L and waist >94 cm randomized to TT (50-100 mg/day, n = 20), placebo (n = 18), or strength training (ST) (n = 16) for 24 weeks. Moreover,(More)
Ant supercolonies (large networks of interconnected nests) represent the most extreme form of multi-queen breeding (polygyny) and have been found across ant lineages, usually in specific long-term stable populations. Many studies on the genetic population structure and demography of ant supercolonies have been done in recent decades, but they have lacked(More)
Medical Image Computing and Computer-Assisted Intervention (MICCAI) is the premier international conference for research in medical image processing and analysis, computer assisted intervention, and medical robotics. MICCAI brings together engineers, clinicians, computer scientists, biologists, physicists, and other researchers and offers them a forum to(More)
PURPOSE We investigated the use of a simple calibration method to remove bias in previously proposed approaches to image-derived input functions (IDIFs) when used to calculate the metabolic uptake rate of glucose (K(m)) from dynamic [(18)F]-FDG PET scans of the thigh. Our objective was to obtain nonbiased, low-variance K(m) values without blood sampling. (More)