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This paper presents a real-time implementation of a topological localization method based on matching image features. This work is supported by a unique sensor pod design that provides stand-alone sensing and computing for localizing a vehicle on a previously traveled road. We report extensive field test results from outdoor environments, with the sensor(More)
AIM A decline in the rate of transition to psychosis in patients presenting with clinical high-risk has been reported in the literature. Several hypotheses have been put forward to explain this decline. In this brief report, we aimed to explore whether the demographic group presenting to clinical high-risk services differs from the 'end-point' population(More)
OBJECTIVES Mood instability is a clinically important phenomenon but has received relatively little research attention. The objective of this study was to assess the impact of mood instability on clinical outcomes in a large sample of people receiving secondary mental healthcare. DESIGN Observational study using an anonymised electronic health record case(More)
OBJECTIVES To identify negative symptoms in the clinical records of a large sample of patients with schizophrenia using natural language processing and assess their relationship with clinical outcomes. DESIGN Observational study using an anonymised electronic health record case register. SETTING South London and Maudsley NHS Trust (SLaM), a large(More)
BACKGROUND Bipolar disorder is a significant cause of morbidity and mortality. Although existing treatments are effective, there is often a substantial delay before diagnosis and treatment initiation. We sought to investigate factors associated with the delay before diagnosis of bipolar disorder and the onset of treatment in secondary mental healthcare. (More)
BACKGROUND Studies indicate that risk of mortality is higher for patients admitted to acute hospitals at the weekend. However, less is known about clinical outcomes among patients admitted to psychiatric hospitals. AIMS To investigate whether weekend admission to a psychiatric hospital is associated with worse clinical outcomes. METHOD Data were(More)
Observational research using data from electronic health records (EHR) is a rapidly growing area, which promises both increased sample size and data richness - therefore unprecedented study power. However, in many medical domains, large amounts of potentially valuable data are contained within the free text clinical narrative. Manually reviewing free text(More)
OBJECTIVES To investigate the association between antidepressant therapy and the later onset of mania/bipolar disorder. DESIGN Retrospective cohort study using an anonymised electronic health record case register. SETTING South London and Maudsley National Health Service (NHS) Trust (SLaM), a large provider of inpatient and community mental healthcare(More)
BACKGROUND Cannabis is frequently used among individuals with first episode psychosis and is associated with poor clinical outcomes. However, little is known about the effect of cannabis use on the response to antipsychotic medications and how use could affect outcomes. Using natural language processing on clinical data from a large electronic case(More)