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Introduction: With the so-called OMICS technology the scientific community has generated huge amounts of data that allow us to reconstruct the interplay of all kinds of biological entities. The emerging interaction networks are usually modeled as graphs with thousands of nodes and tens of thousands of edges between them. In addition to sequence alignment,(More)
Motivation: We address the problem of multiple protein-protein interaction (PPI) network alignment. Given a set of such networks for different species we might ask how much the network topology is conserved throughout evolution. Solving this problem will help to derive a subset of interactions that is conserved over multiple species thus forming a 'core(More)
The systemic injection of oxytocin (OXT) decreases the self-administration of heroin in heroin-tolerant rats. Since OXT-ergic binding sites are present in limbic and mesolimbic brain regions, the effects of intracerebral microinjections of OXT were investigated. In heroin-tolerant rats, the microinjection of OXT (2 ng) into the anterodorsal part of the(More)
The role of lysine-vasopressin and oxytocin, as well as of their analog and fragment (DGAVP, desglycinamide arginine vasopressin; PLG, prolyl-leucyl-glycyl-amine), microinjected into the ventral hippocampus, in the formation and extinction of active avoidance conditioned reflex, was investigated. It was established that the introduction of(More)
Motivation: A growing number of biological networks of ever increasing sizes are becoming available nowadays, making the ability to solve Network Alignment of primer importance. However, computationally the problem is hard for data sets of real-world sizes. Results: we developed NABEECO, a novel and robust Network Alignment heuristic based on Bee Colony(More)
MOTIVATION In the systems biology era, high-throughput omics technologies have enabled the unraveling of the interplay of some biological entities on a large scale (e.g. genes, proteins, metabolites or RNAs). Huge biological networks have emerged, where nodes correspond to these entities and edges between them model their relations. Protein-protein(More)
The peripheral blood and central lymph of rats under experimental myocardial infarction was studied by means of light microscopy and electric conductivity measurement. Both hypertensive rats and animals 3 days after myocardial infarction had similar quantity of neutrophils in peripheral blood. Lymph cells count of hypertensive rats by middle lymphocytes is(More)
Intraventricular injection of oxytocin exerted a selective effect on catecholamine metabolism in microchondrial fractions of different brain formations of normal and narcotic drug-dependent animals. The drug-dependent group showed a higher level of the brain catecholamines as compared to the controls, oxytocin decreasing the catecholamine level in this(More)