Kazem Behbehani8
Sardar Sindhu6
Said Dermime3
Fahad Al-Ghimlas3
Amal Hasan3
8Kazem Behbehani
6Sardar Sindhu
Learn More
Expression profile of the toll like receptors (TLRs) on PBMCs is central to the regulation of proinflammatory markers. An imbalance in the TLRs expression may lead to several types of inflammatory disorders. Furthermore, the dynamic regulation of inflammatory activity and associated impaired production of cytokines by peripheral blood mononuclear cells(More)
  • Rasheed Ahmad, Anfal Al-Mass, Dalal Al-Ghawas, Nada Shareif, Nadia Zghoul, Motasem Melhem +4 others
  • 2013
BACKGROUND/OBJECTIVE Osteopontin (OPN) and IL-18 are known inflammatory mediators and both participate in a wide range of biological processes linked to immunological disorders. Since an interaction between OPN and IL-18 has not been studied in obesity, we investigated whether: (i) their levels were simultaneously elevated in obese individuals; (ii) OPN was(More)
  • Sardar Sindhu, Reeby Thomas, Puthiyaveetil Shihab, Devarajan Sriraman, Kazem Behbehani, Rasheed Ahmad +1 other
  • 2015
The role of IL-6R/IL-6 axis in metabolic inflammation remains controversial. We determined the changes in adipose tissue expression of IL-6R and IL-6 in obese, overweight, and lean non-diabetic individuals. Subcutaneous adipose tissue biopsies were collected from 33 obese, 22 overweight, and 10 lean individuals and the expression of IL-6R, IL-6, TNF-α,(More)
The polysaccharide fraction from Solanum nigrum Linne has been shown to have antitumor activity by enhancing the CD4+/CD8+ ratio of the T-lymphocyte subpopulation. In this study, we analyzed a polysaccharide extract of S. nigrum to determine its modulating effects on RAW 264.7 murine macrophage cells since macrophages play a key role in inducing both innate(More)
BACKGROUND The prevalence of obesity is rising. Obesity can lead to cardiovascular and ventilatory complications through multiple mechanisms. Cardiac and pulmonary function in asymptomatic subjects and the effect of structured dietary programs on cardiac and pulmonary function is unclear. OBJECTIVE To determine lung and cardiac function in asymptomatic(More)
Recent studies have demonstrated a protective role for IL-33 against obesity-associated inflammation, atherosclerosis and metabolic abnormalities. IL-33 promotes the production of T helper type 2 (Th2) cytokines, polarizes macrophages towards a protective alternatively activated phenotype, reduces lipid storage and decreases the expression of genes(More)
  • Eleonora Poggiogalle, Carla Lubrano, Lucio Gnessi, Stefania Mariani, Andrea Lenzi, Lorenzo Maria Donini +1 other
  • 2016
INTRODUCTION Recently the association between hepatic steatosis and sarcopenia has been described. GH/IGF-1 axis has been postulated to play a role in linking fatty liver and low muscle mass. The aim of our study was to explore the association between fatty liver index, sarcopenic obesity, insulin sensitivity, and GH/IGF-1 status. METHODS 427 subjects(More)
  • Sandra N. Slagter, Jana V. van Vliet-Ostaptchouk, André P. van Beek, Joost C. Keers, Helen L. Lutgers, Melanie M. van der Klauw +2 others
  • 2015
BACKGROUND Health-related quality of life (HR-QoL) may be compromised in obese individuals, depending on the presence of other complications. The aim of this study is to assess the effect of obesity-related conditions on HR-QoL. These conditions are i) grade of obesity with and without type 2 diabetes (T2D), ii) metabolic syndrome (MetS), and iii) level of(More)
Fetuin-A/AHSH is a novel hepatokine that acts as a vascular calcification inhibitor and as an endogenous TLR-4 ligand. Fetuin-A may act as a positive or negative acute phase protein (APP) in disease conditions. The relationship between circulatory fetuin-A and inflammatory biomarkers in type-2 diabetes (T2D) remains controversial. Therefore, the purpose of(More)