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The G1 restriction point is critical for regulating the cell cycle and is controlled by the Rb pathway (CDK4/6-cyclin D1-Rb-p16/ink4a). This pathway is important because of its inactivation in a majority of human tumors. Transition through the restriction point requires phosphorylation of retinoblastoma protein (Rb) by CDK4/6, which are highly validated(More)
Recently discovered, angiotensin-converting enzyme-2 (ACE2) is an important therapeutic target in the control of cardiovascular diseases as a result of its proposed central role in the control of angiotensin peptides. Thus our objective in the present study was to determine whether ACE2 gene transfer could decrease high blood pressure (BP) and would improve(More)
Targeting mitotic regulators as a strategy to fight cancer implies the development of drugs against key proteins, such as Aurora-A and -B. Current drugs, which target mitosis through a general mechanism of action (stabilization/destabilization of microtubules), have several side effects (neutropenia, alopecia, and emesis). Pharmaceutical companies aim at(More)
l-ascorbic acid (vitamin C) is an abundant metabolite in plant cells and tissues. Ascorbate functions as an antioxidant, as an enzyme cofactor, and plays essential roles in multiple physiological processes including photosynthesis, photoprotection, control of cell cycle and cell elongation, and modulation of flowering time, gene regulation, and senescence.(More)
The long term impact of microwave communication technologies will be functionality simulated and design on traditional computing and usual RF and microwave communication simulators such us: PSPICE, Agilent ADS, Agilent GENESYS, AWR Microwave Office, etc. This ability, allows making possible the enabling of the digital computer interaction and simulation(More)
This document is dedicated to my fiancé, Jason, and my family for their continued love and encouragement. iv ACKNOWLEDGMENTS First, I would like to thank my committee members, Drs. Each has contributed to my development as a scientist in many different ways. I would like to thank my mentor, Dr. Yezierski, for teaching me all there is to know about spinal(More)
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