Raquel Ramos Pinho

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The pathogenesis of many neurodegenerative disorders arises in association with the misfolding and accumulation of a wide variety of proteins. Much emphasis has been placed on understanding the nature of these protein accumulations, including their composition, the process by which they are formed and the physiological impact they impose at cellular and,(More)
This paper presents a physics-based approach to obtain 2D or 3D dynamic pedobarography transitional objects from two given images (2D or 3D). With the used methodology, we match nodes of the input objects by using modal matching, improved with optimization techniques, and solve the Lagrangian dynamic equilibrium equation to obtain the intermediate shapes.(More)
Spinal lamina I receives nociceptive primary afferent input to project through diverse ascending pathways, including the anterolateral tract (ALT). Large projection neurons (PNs) form only a few per cent of the cell population in this layer, and little is known about their local input from other lamina I neurons. We combined single-cell imaging in the(More)
Tuberous sclerosis complex (TSC) is associated with hamartomatous growths including subependymal giant cell astrocytomas (SEGAs). Although, SEGAs are slow-growing glioneuronal tumors, they represent a significant cause of morbidity and mortality due to the risk of sudden death from acute hydrocephalus. Neurosurgical resection has been the mainstay of(More)
Spinal lamina I is a key area for relaying and integrating information from nociceptive primary afferents with various other sources of inputs. Although lamina I projection neurons have been intensively studied, much less attention has been given to local-circuit neurons (LCNs), which form the majority of the lamina I neuronal population. In this work the(More)
Synucleinopathies are a group of progressive disorders characterized by the abnormal aggregation and accumulation of α-synuclein (aSyn), an abundant neuronal protein that can adopt different conformations and biological properties. Recently, aSyn pathology was shown to spread between neurons in a prion-like manner. Proteins like aSyn that exhibit(More)
This paper presents a methodology to do morphing between image represented objects, attending to their physical properties. It can be used amongst images of different objects, or otherwise, between different images of the same object.According to the used methodology the given objects are modelled by the Finite Element Method, and some nodes are matched by(More)
In this paper we present a management model to deal with the problem of tracking a large number of features during long image sequences. Some usual difficulties are related to this problem: features may be temporarily occluded or might even have disappeared definitively; the computational cost involved should always be reduced to the strictly necessary. The(More)
This paper addresses the problem of tracking feature points along image sequences to analyze the undergoing human movement. An approach based on Kalman filtering performs the estimation and correction of the feature point’s movement in every image frame, and optimizes the incorporation of the measured data in order to establish the best global(More)
This work addresses the problem of tracking feature points along image sequences. In order to analyze the undergoing movement, an approach based on the Kalman filtering technique has been used, which basically carries out the estimation and correction of the features’ movement in every image frame. So as to integrate the measurements obtained from each(More)