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Ascertaining when and where genes are expressed is of crucial importance to understanding or predicting the physiological role of genes and proteins and how they interact to form the complex networks that underlie organ development and function. It is, therefore, crucial to determine on a genome-wide level, the spatio-temporal gene expression profiles at(More)
The diencephalon is a central area of the vertebrate developing brain, where the thalamic nuclear complex, the pretectum and the anterior tegmental structures are generated. It has been subdivided into prosomeres, which are transversal domains defined by morphological and molecular criteria. The zona limitans intrathalamica is a central boundary in the(More)
To provide a temporal framework for the genoarchitecture of brain development, we generated in situ hybridization data for embryonic and postnatal mouse brain at seven developmental stages for ∼2,100 genes, which were processed with an automated informatics pipeline and manually annotated. This resource comprises 434,946 images, seven reference atlases, an(More)
Fate-map studies have provided important information in relation to the regional topology of brain areas in different vertebrate species. Moreover, these studies have demonstrated that the distribution of presumptive territories in neural plate and neural tube are highly conserved in vertebrates. The aim of this review is to re-examine and correlate the(More)
Oligodendrocytes are the myelin-forming cells in the central nervous system of vertebrates. Oligodendrocyte precursors arise from multiple restricted foci distributed along the antero-posterior axis of the developing brain. In chick and mouse embryos, oligodendrocyte precursors of the anterior forebrain emerge from neuroepithelial cells of the subpallium(More)
Regionalization of the neural tube is a fundamental event in the development of the CNS. The isthmic organizer controls the development of the mesencephalic-rhombencephalic junction by means of fibroblast growth factor 8 (Fgf8) expression. The transcription factor paired box 2 (Pax2) is expressed early in the midbrain and is later progressively restricted(More)
  • Luca Pasquini, A Manescau, G Avila, B Delabre, H Dekker, J Liske +30 others
  • 2008
1 The Drivers In the frame of the call for proposal for the E-ELT instrumentation studies, the CODEX team carried out the feasibility study for a spectrograph for extremely stable Doppler measurements. The CODEX project and its scientific goals are described in [6]. During the development of this study, the CODEX team recognized that a CODEX-like instrument(More)
General rights Copyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights. Take down policy The University of Edinburgh has made every(More)
1988 : Member of the "Academia Europea" 1993 : " Neuronal Plasticity International Prize " from IPSEN Foundation 1998 : Doctor " honoris causa " from Sevilla University Cajal: The anatomical organization of the cortex of the cerebellum. Can the neuron doctrine still support our actual knowledge on the cerebellar structural arrangement? Cerebellar(More)
LIS1 is one of principal genes related with Type I lissencephaly, a severe human brain malformation characterized by abnormal neuronal migration in the cortex. The LIS1 gene encodes a brain-specific 45kDa non-catalytic subunit of platelet-activating factor (PAF) acetylhydrolase-1b (PAFAH1b), an enzyme that inactivates the PAF. We have studied the role of(More)