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Ascertaining when and where genes are expressed is of crucial importance to understanding or predicting the physiological role of genes and proteins and how they interact to form the complex networks that underlie organ development and function. It is, therefore, crucial to determine on a genome-wide level, the spatio-temporal gene expression profiles at(More)
The diencephalon is a central area of the vertebrate developing brain, where the thalamic nuclear complex, the pretectum and the anterior tegmental structures are generated. It has been subdivided into prosomeres, which are transversal domains defined by morphological and molecular criteria. The zona limitans intrathalamica is a central boundary in the(More)
The vertebrate Central Nervous System (CNS) originates from the embryonic dorsal ectoderm. Differentiation of the neural epithelium from the ectoderm and the formation of the neural plate constitute the first phase of a complex process called neurulation which culminates in the formation of the neural tube, the anlage of the CNS in sauropsids and mammals(More)
To provide a temporal framework for the genoarchitecture of brain development, we generated in situ hybridization data for embryonic and postnatal mouse brain at seven developmental stages for ∼2,100 genes, which were processed with an automated informatics pipeline and manually annotated. This resource comprises 434,946 images, seven reference atlases, an(More)
While the origin of oligodendroglia in the prosencephalon and spinal cord has been extensively studied and accurately described, the origin of this cell type in the cerebellum is largely unknown. To investigate where cerebellar oligodendrocytes generate and which migratory pathways they follow to reach their final destination in the adult, in ovo(More)
Fate-map studies have provided important information in relation to the regional topology of brain areas in different vertebrate species. Moreover, these studies have demonstrated that the distribution of presumptive territories in neural plate and neural tube are highly conserved in vertebrates. The aim of this review is to re-examine and correlate the(More)
Oligodendrocytes are the myelin-forming cells in the central nervous system of vertebrates. Oligodendrocyte precursors arise from multiple restricted foci distributed along the antero-posterior axis of the developing brain. In chick and mouse embryos, oligodendrocyte precursors of the anterior forebrain emerge from neuroepithelial cells of the subpallium(More)
OBJECTIVE To examine the effectiveness of playing chess as a treatment option for children with ADHD. METHODS Parents of 44 children ages 6 to 17 with a primary diagnosis of ADHD consented to take part in the study. Parents completed the Spanish version of the Swanson, Nolan and Pelham Scale for parents (SNAP-IV) and the Abbreviated Conner's Rating Scales(More)
Mesenchymal stem cells (MSCs) are defined as progenitor cells that give rise to a number of unique, differentiated mesenchymal cell types. This concept has progressively evolved towards an all-encompassing concept including multipotent perivascular cells of almost any tissue. In central nervous system, pericytes are involved in blood-brain barrier, and(More)
Sulfatase 1 is a secreted enzyme that modulates the sulfation state of heparan sulfate proteoglycans (HSPGs), which are potential key regulators of diverse developmental signals during embryonic patterning. In the present work, we have analyzed the Sulf1 gene expression pattern during chicken forebrain development. Our results indicate that, at early(More)